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The cool new DIY science movement that's changing everything from animals to agriculture.

"We're all here because we want to be the first humans able to fly."

"And we also want to live forever, see through walls, and shoot lasers from our eyeballs," the Ukrainian scientist tells me with a totally straight face. "But that's all science-fiction nonsense for now. So in the meantime, we're just making yogurt with an anti-aging protein, and things like that."


That must be Stamos' secret. GIF from Dannon Oikos/YouTube.

We're standing in the attic of a bicycle repair shop in Somerville, Massachusetts, where a group of local scientists and curious hobbyists have built a do-it-yourself laboratory for homegrown biology experiments.

The space is strewn with secondhand equipment, all scavenged and salvaged from the dumpsters of nearby universities and major pharmaceutical companies. Someone even found a way to use a breast pump to filter out bacteria samples. Yeah.

But as wild as this all may sound, it's hardly the most remarkable thing to come out of the life science revolution that's sweeping across the world.

"I cannot believe my eyes!" — Me, when I saw this stuff. GIF from "Dr. Horrible's Sing-Along Blog."

Recent advancements in biotech have made it easier than ever to manipulate and edit DNA with shocking accuracy.

At the forefront of this biological renaissance is a little thing scientists call CRISPR-Cas9, often shortened to just plain ol' CRISPR. It's a system that we pretty much stole from certain bacteria that uses enzymes and something called guide RNA to target and cut sequences of DNA.

But that's all kinds of confusing for non-science-y types, so think of it like this: DNA is full of information that tells a story, like a book. Previously, if we wanted to change any part of this DNA-book, we had to chop up random sections with our metaphorical scissors, or splash white-out on the pages, trying to scribble in new notes wherever we could. Sure, it got the job done sometimes. But it was also pretty messy and inefficient.

The CRISPR system offers a new kind of "find-and-replace" feature. Now we can take our DNA-book and say, "OK, CRISPR, please find that sentence that specifically says, 'Harry met Hagrid.'" Then we can tell it to cut out that particular sentence and either get rid of it entirely or add our own new, much cooler sentence in its place. (Like "Harry met Hagrid and then they high-fived and it was so epic that they destroyed Voldemort and everyone was awesome.")

Got that?

TL;DR: Everything is awesome with CRISPR. GIF from "The LEGO Movie."

Now imagine that instead of just rewriting their own derivative Harry Potter fanfic, scientists can use this "find-and-replace" feature to turn specific genes "on" or "off," or even add new sequences of base pairs into the genome. This makes it easier than ever to go in and splice, add, or change one little piece of genetic information and see what happens.

"It's like a toolkit, essentially," explained Joanne Kamens, executive director of Addgene. "It's like having just the right screwdriver we never had, and it's allowing scientists to create hundreds of new tools and making everything exponentially faster."

A much-more useful CRISPR explainer video. GIF from Desktop Genetics/YouTube.

This kind of super-accurate gene editing — and genetic synthesis in general — have become more accessible in the past few years.

CRISPR might be the prom queen of the biggest labs, but there are other similar versions of this kind of precision gene-editing technology — like the methods that my Ukrainian friend was using in that attic. And these tools are collectively changing the world as we know it, in attics and labs all over the world.

Let's go down the DNA rabbit hole... GIF from McGovern Institute for Brain Research at MIT/YouTube.

Here are five of the most fascinating inventions and discoveries we've seen in biotech to date:

1. Gene editing could help us limit, or maybe even destroy, diseases like malaria and cancer.

Now that we can slice into DNA with alarming accuracy, we can target exactly where diseases exist in the body and how drugs get delivered to kill those diseases. It's like a microbiological version of "Mission: Impossible" when you're trying to defuse a bomb — gene editing tells you exactly which wire to cut, without the risk of blowing up the building (which in this case is a human body).

Scientists at the University of California San Francisco, for example, have found a way to turn human T cells into hyper-efficient disease-killing machines. Similarly, at Temple University, researchers are using CRISPR to literally cut HIV out of live subjects. Pretty neat, huh?

As for those pesky mosquito-born illnesses plaguing our warming world, CRISPR has already made it easier to identify diseases such as Zika, malaria, and West Nile in patients and hosts alike — and some scientists hope to use gene editing to remove the disease-carrying capability from the mosquito genome entirely, destroying them at the source.

EXACTLY. GIF from "Adventure Time."

2. This same application is revolutionizing how we study mental health, too.

Scientists at MIT have already used gene editing to create lab mice with autism and OCD so they can better understand what causes those conditions and how best to treat them.

If they can create those conditions, they might be able to un-create them, too, by essentially flipping a switch on the problematic genes. (The only trick is figuring out with certainty which specific genes out of the billions in our body are causing the problems, which is easier said than done.)

I know, Krang. It's pretty mind-blowing. GIF from "Teenage Mutant Ninja Turtles."

3. It could also help us bring back the wooly mammoth or any other number of crazy chimera breeds.

Yup: Scientists at Harvard University successfully spliced wooly mammoth DNA into elephant cells. This is just on a cellular level so far, mind you; no one's prepared to go all "Jurassic Park" without looking into all the potential ramifications of such a project.

But, I mean, you knew this was coming, right? As cool and generally comforting as these other remarkable projects have been, we're still talking about genetic engineering, so of course there'd be some kind of super-powered kaiju-animal hybrids in the cards.

In China, scientists have already used CRISPR to breed dogs with twice the muscle mass by simply deleting one gene from their DNA. And in Boston, they've found a way to modify pig organs to make them compatible with human bodies in need of transplant donors.

And if you're wondering about the practical applications and ethical justifications of these kinds of projects, well ... those are totally valid things to be concerned about. But scientists are actively engaged in those discussions, and if it makes you feel any better, we're probably still a long way away from creating fully customizable mature synthetic humans. Probably.


My thoughts exactly, Doc Brown. GIF from "Back to the Future."

4. Gene editing could also help to revamp the entire agriculture industry — without the use of any off-putting genetic additives.

GMOs get a bad wrap. But gene editing is different from, say, adding a bit of flounder DNA into a tomato, which is why the FDA recently approved the first CRISPR-modified mushroom for human consumption.

These specially designed mushrooms have a greater resistance to browning — again, not because of any scary-sounding chemicals or foreign genes, but simply because biologists found a way to isolate and shut off the naturally occurring genes that caused the mushrooms to turn brown after you cut into them.

That's it. Really. Nothing scary about it.

Naturally occurring mushroom-hat parachutes are still in the early developmental stages. GIF from "Super Mario Bros. Super Show."

This method is also working to create disease-resistant plants, which is how a team at Seoul National University is trying to save the banana. Because why bother introducing pesticides or foreign genetic material when you can just poke at the DNA that the plant already has to improve its nutrient content and help it survive under less-than-ideal conditions? It's not quite "natural" in the traditional sense, but it's also not so different from the exchange and selective breeding of crops that's been going on for centuries.

Just, ya know — easier, and cooler-sounding.

So that's what Beaker's been meeping about all these years! GIF from "The Muppet Show."

5. But perhaps most importantly, gene editing is lowering the bar for scientific research and making it accessible to everyone.

Until recently, a lot of genetic and biotech data was protected behind intellectual property laws and institutional restrictions. But now? Anyone can buy an all-in-one CRISPR starter kit online or order a plasmid straight from a place like Addgene for a mere $65 and see what they can do with it ... just like those guys in the Somerville attic.

"It's like designing apps" for smartphones, said DeskGen's A.J. Ajetunmobi. DeskGen is a biotech startup that offers free open-source desktop gene-editing software, allowing anyone to design an experiment from anywhere in the world.

"People can focus on fixing problems instead of learning how to code," he said. "In life sciences, we're still stuck teaching people how to code. It's hard to teach that and still keep minds open."

GIF from "Dexter's Laboratory."

"Diversity of perspective makes everything better. People are so much more innovative when they're not coming at it from a specific overhead," Ajetunmobi added.

The possibilities for progress are endless as long as the opportunities are available to everyone — not just the pharmaceutical companies who can afford to pay millions for special equipment and data.

"The barriers to entry [in biotech] are significant," Ajetunmobi told me with an eyeroll and a laugh, before pointing out that it would be logistically difficult for an individual — say, a 30-year-old writer who is me — to obtain all the necessary plasmids and parts to breed a personal army of altruistic disease-resistant pig-human hybrid super-farmers with laser vision and flight capabilities.

"But now, there's nothing technically stopping anyone from experimenting and exploring."

Maybe you, too, can create your own web-shooters! ... Maybe. GIF from "The Amazing Spider-Man."

Personally, I decided to keep it simple and stick with the DIY bioluminescent yeast starter kit.

I'll leave the cool sci-fi-sounding progress to the pros (or to my new friends trying to find the fountain of youth in yogurt). But it's still nice to know that the opportunity is out there for anyone eager enough to give it a try.

Who knows? Maybe that 14-year-old kid next door will find a way to make pigs fly sooner than we think.

A dad got a sweet note from a fellow father after camping with his kids.

One of the hardest parts of being a parent is never being sure whether you're doing a good job or totally bombing it. If you're conscientious enough to even wonder if you're a good parent, you probably are, but parenting entails a million little choices and interactions, and there's always a lingering voice in your head saying, "What if you're really screwing this whole thing up?"

Reassurance and encouragement are always appreciated by parents, but not always received, which is why a note from one camping dad to another has people celebrating the kindness of anonymous strangers.

"You are killing it as a dad."

Someone on Yosemite Reddit thread shared a photo of a handwritten note with the caption, "To the man who left this thoughtful note on my windshield at Lower Pines Campground this weekend, I extend my heartfelt gratitude; your acknowledgment of my efforts to be a good father means a great deal to me."



The note reads:

"Bro,

I camped in the spot behind you last night. Let me just say, you are killing it as a dad. First off, I watched your wife guide you in as you backed up your trailer and nailed it on the first try without any yelling. Then your kids unloaded from the truck and were mild-mannered and well behaved. You told stories around the campfire and I had the pleasure of listening to the sounds of giggles and laughter.

From one dad to another, you are killing it. Keep it up.

P.S. Whatever you cooked for dinner smelled delicious!"

How often do we share these thoughts with strangers, even if we have them? And who wouldn't love to get a surprise bit of praise with specific examples of things we did right?

Everyone needs to hear a compliment once in a while.

So many people found the note to be a breath of fresh air and a good reminder to compliment people when we feel the urge:

"That would make any daddy's eyes water."

"It’s always nice, as a guy, to get a compliment."

"I complimented a guy's glasses at work (I'm also a guy, and btw they were really cool glasses, I wasn't just being nice) and now he keeps trying to tell me where he got his glasses and how I should get some. But I'm just having to be polite because I already have glasses and I'm not in the market. I finally had to tell him I'm not going to buy them lmao I just like them on him.

Made me feel like that's the first compliment he's had in years because he can't stop talking about it. Also I mainly liked the glasses because I think he's cute but he really thinks it's just the glasses haha jokes on him that cute bastard."

"I was in the store with my wife and one of our 'adopted nephews' yesterday (we’re close friends with his parents and we’ve known him and his brother since they were newborns and 2yo, respectively). A woman came up to me at checkout while my wife was running out to the car and said 'I’m not sure what your family relationship is here, but I just have to tell you how nice and refreshing it is to hear all the laughter and joy from the 3 of you. You both seem like such a good influence on him and it warms my heart.' It’s such a small thing but as a dude, I can’t remember the last time someone gave me a compliment in public and it made my freaking day."

"10/10 letter. The and not yelling part gave me a good chuckle lol."

"We need so much more of men getting such heartfelt and sincere compliments. Thanks for sharing. ❤️"

"I’ve never considered leaving a note, but when I see a harmonious family with good parenting, it’s healing for me. My childhood was awful."

"Such an awesome compliment! Even though I don't have children myself, I like to remind my friends too that they're doing great & it brings them happy tears."

"This made me cry. I love that you are getting your 'flowers.' My dad sucked, I’m so glad you are one of the good ones."

"This made me cry too. It’s so hard to be a human. Let alone a parent. Getting a good job sticker every now and then really means a lot these days."

"I'm a big bearded guy and I would cry if I got this note. More people like this, please."

The best part of this story is that no one knows who the dad who wrote the note is, not even the dad who shared it. It wasn't written for clout or notoriety, it wasn't to get attention or make himself look good. No name or signature, just an anonymous act of kindness to uplift a stranger whether he needed it or not.

We all need to hear or read kind things said about us, and sometimes it means even more coming from an anonymous stranger who has nothing to gain by sharing. A good reminder to share it when you feel it—you never know how many people you may move and inspire.

This article originally appeared last year.

All screenshots from @lakynbowman on TikTok.

It was Grandma’s 71st birthday, and granddaughter Lakyn Bowman came up with the cutest, cleverest and most thoughtful way to honor the occasion.

Bowman (@lakynbowman) shared in a TikTok video that after going through old photos, she realized just how much they both looked alike. And so, to thank grandma for passing down the good genes, she decided to recreate each signature look. After a few rounds with a curling iron, some pale blue eyeshadow, and throwing on some charming floral prints (plus some filter wizardry to give the pics that retro look) the resemblance is just uncanny.

People were delighted to see such a loving tribute. The video quickly racked up over 8 million views, with more than a few comments talking about how emotional the tribute made them. Can’t say I blame 'em.

Screenshot of a comment

Such a heartwarming tribute obviously moved some to tears.

TikTok

But how did grandma feel about it? Well, in a follow-up video, we see a genuine ear-to-ear smile. Suffice it to say, the idea was a hit.

As one person wrote to Bowman, “you’ll never be able to top this gift.”

It certainly helps that Bowman is vintage savvy. She even helps others find amazing secondhand items through her company Nine Oh Six. So getting the clothes and accessories was a piece of old-fashioned pineapple upside-down cake. And the results were just as sweet. Take a look below:

@lakynbowman Happy birthday, Grandma! Thanks for the good genes. 💕 #recreate#photoshoot #birthdayphotoshoot #vintage #grandma ♬ What Once Was - Her's
@lakynbowman

Reply to @katemason06 The audio didn’t save. 😭 But here’s her reaction. I love her so much! 💕

These videos are not only an instant dash of joy, it’s also a heartwarming reminder that our elders provide the prologue to our life stories. Honoring them can be as simple or creative as we want them to be, but be sure to include them. As we can see with this grandma-granddaughter duo, it’ll mean the world to them.


This article originally appeared three years ago.

There's a big change at the 98th meridian.

Have you ever wondered why the eastern half of the United States is densely populated while everything west of Omaha, save for a few metro areas, is no man’s land?

Most people would assume that it’s because people first settled in the east and moved west. Or, they may believe it’s because of the vast desert that takes up most of the southwest. Those are some decent reasons, but it’s a much more complicated issue than you'd imagine.

A 20-minute video by RealLifeLore explains how topography and rainfall have created what appears to be a straight line down the middle of the country on the 98th meridian that dictates population density. Eighty percent of Americans live on the east side of the line and just twenty percent to the west.

RealLifeLore is a YouTube channel that focuses on geography and topography created by Joseph Pisenti.

In the video, we see that several large cities border the American frontier—San Antonio, Austin, Fort Worth, Oklahoma City, Wichita, Omaha, Lincoln, Sioux Falls, and Fargo, as well as Winnipeg up in Canada. To the west of those cities? Not much until you reach western California and the Pacific Northwest.

Why? Watch:

The major reason why the population drastically changes is rainfall. It rains much more on the east side of the line versus the west. The reason for the drastic change in rainfall is that the Rocky Mountains create a colossal wall known as a rain shadow that prevents moisture from passing from the Pacific Ocean. This has created a large swath of dry land that’s not conducive to larger populations.

Though the eastern U.S. is more densely populated, it doesn't mean the west doesn't sometimes feel crowded, especially if you live in Los Angeles County. What side of the line are you on?

This article originally appeared three years ago.

Man praised for not switching seats with dad traveling with daughter

Airlines charge for everything but breathing nowadays so people tend to be protective of their seat assignments. They picked them with their own hands with their needs and preferences in mind before paying the extra money to confirm the seating. Choosing your own seat can range from $5-$80 extra per ticket depending on where in the cabin you choose to sit, barring first class options.

It's for this reason that people aren't keen on trading their seats with someone who chose to let the airline auto-assign a seat for them. This doesn't stop people from asking unsuspecting fellow travelers to swap seats with them, likely relying on the social pressure of the situation to coax a yes. But one man refused to be swayed, even when the other passenger points out that he would like to sit next to his minor daughter which may have been enough to encourage others to oblige the request.

The passenger who was being asked to move had already paid additional money to sit in an aisle seat he explains, "I always book an aisle seat. My company allows me to add the small surcharge for an aisle seat (it was $18). I sat early and this guy comes with his daughter. His daughter had the middle seat next to me. He had another middle seat elsewhere. He asked to switch with me. I said I would if he had an aisle seat. He said he has a middle seat."

Season 9 Ugh GIF by Curb Your EnthusiasmGiphy

The middle seat is typically the least desirable seat due to being stuck between two other passengers, no designated armrest and nothing to comfortably lean your head on should you fall asleep. Waking up only to realize you've been asleep on a stranger's shoulder can make for an awkward interaction, so there's no surprise the man didn't want to trade seats with the dad on those details alone. But the man didn't choose the aisle seat because he was afraid of drooling on the shoulder of a fellow passenger.

"I said sorry, I am a big guy (6 feet, 260+ pounds), I am [un]comfortable in middle seat. It's a 4.5 hour flight," the befuddled passenger shares before adding. "I explained I am physically uncomfortable in the middle. The aisle gives me more room."

Giphy

One might think the interaction would end there but it didn't. According to the six-foot-tall man, the dad then involved a flight attendant to encourage him to give up his seat so the dad could sit next to his child. But the man continued to refuse the dad's request which resulted in the dad having to sit in his original seat and the teenage girl being seated next to the original man. He had no desire to be uncomfortable for a fairly long flight and while he was expecting for people to disagree with his actions, they were overwhelmingly on his side.

"You paid extra for that aisle seat, and it’s your comfort on a long flight. The guy should've booked better seats if he wanted to sit next to his daughter. Plus, it’s not your job to accommodate his poor planning," one person writes.

No Way Beer GIF by BuschGiphy

"If you want to sit together, pay for the seats. Good for you, people like that need to learn they cant have their cake and eat it too," someone else says.

"I hate it when a FA asks you to move one you've already said no. They should stand by their company who sold you the seat and reiterate that to the person asking," another chimes in.

pushing air travel GIFGiphy

"I’ve been in the situation traveling, when my kids were small and flights were canceled, etc. that we were seated separately. When you REALLY do NEED compassion, people are generally OK with it and they are understanding and will likely move if able. I’ve also raised my kids to be independent and as teenagers they would have been just fine. In a case where it really is a need (like a special needs teen), the airline owes its passengers some sort of a solution like upgrading an inconvenienced traveller," someone else adds.

The man does admit that maybe the dad assumed the solo traveler would be inappropriate with his daughter saying, "Maybe he thought I was some creeper? I AM NOT. I popped a prescription muscle relaxer, put on relaxing music on my earphones and zoned out." In the end the man did not give up his seat and the teen girl and her father were both fine sitting in the seats assigned to them.

Life is bigger than the U.S.!

Dreaming about moving to another country and starting over is no longer just a dream for some people. A growing number of millennial expats are finding their American dream in another country. And they're taking to social media to invite us to follow their journeys. Living comfortably in America is merely a dream for most people, so seeing expats doing it in other countries is inspiring more people than ever to seek a better life than they can achieve in the United States elsewhere.

Influencer and educator Olumide Gbenro has made a life in Bali that would be unattainable to most Americans. When Gbenro was around 13, his family immigrated to Columbus, Ohio after living in London. Gberno spent the first six years of his life in his home country of Nigeria, so relocating was not new to him. Before deciding to leave it all behind as an adult, Olumide was on a different path. A path his parents had set before him, but one he didn't want to follow.

In 2016, Gberno graduated with two master’s degrees from San Diego State University. One master’s was in epidemiology and the other in behavioral sciences. The new graduate was primed to go on for his PhD just as his parents wanted, but enrolling in a PhD program meant traveling the world would be off the table and the soon to be expat wasn’t ready to give up on it. The choice then became to become a doctor or travel, and since traveling was in his blood it was a no-brainer.

Gberno told CNBC Make It, “All of my life, I just followed the rules, whether it was from my parents, religion or society,” he says. “But deep down I knew that if I took the position in the PhD program, I could never go back, I could never travel abroad...I’d be stuck to a lab, so I decided to say ‘no.’” Shortly after coming to the conclusion that a PhD wasn’t for him, he packed up his belongings and headed out of the country.

Olumide took some time in a few other locations before settling in Bali; the new expat first stopped in Berlin on a three month tourist visa, staying in hostels and couch surfing at friends' houses. Gberno didn’t have much savings when he left America, so not working wasn’t an option, and eventually he struck success with his online business in social media marketing. He was able to grow his Instagram following fairly quickly by posting photos of his adventures and dance videos. With a larger following, he started reaching out to other creators and businesses offering to help improve their social media strategy for the small fee of $250. Eventually, it enabled him to turn it into a lucrative business that helps sustain his lifestyle.

After Olumide’s three months in Berlin were up, he traveled to Mexico and then back to San Diego where he launched his business, Olumide Gbenro PR & Brand Monetization, in 2018. While scrolling through Instagram he saw a post from a friend visiting Bali at the time. The scenery appealed to him, so he decided to go. After many flights back and forth to Singapore and Malaysia to extend his visa 30 days at a time, he was granted an investors visa.

Gberno earns about $140,000 a year and his biggest expense is his rent and utilities which total $1,010 a month. He spends about $600 a month on take out and eating at restaurants and continues to travel at least once a month. Gberno told CNBC “I’m probably spending about the same amount of money I would each month if I was living in San Diego, but my quality of living is much higher,” he says. “I’m living a life of luxury.”

These expats make living abroad look like a feasible goal and for some it is. Be warned that following these adventurous souls on social media may make you want to pack a few bags and never look back.


This article originally appeared three years ago.