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7 mindblowing medical breakthroughs that could occur in our lifetime

One day soon, you might be able to grow new teeth. Seriously.

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My family has a history of Parkinson's Disease, so I always see the headlines that promise some major scientific breakthrough in regards to the disease based on small, lab-based experiments or trials run on animals. They give us a glimmer of hope but, far too often, these treatments never see the light of day. The road from promising idea to having a real treatment available for patients is extremely long and arduous. Most potential new medications and therapies don't survive.

But... things do sometimes happen! There are massive medical breakthroughs being achieved all the time. Sometimes it's a new discovery, sometimes it's a successful clinical trial, and sometimes it's the fruit of all that labor finally becoming publicly available to people who need it the most. For example, an RSV vaccine just became available in 2023 for the first time. A powerful non-opioid pain killer was approved in 2024. A new drug came out to treat schizophrenia that was completely different than anything that had come before. Progress is being made every single year.

In our lifetime, say the next five to 20 years, we could see unbelievable advancements in treating certain medical conditions. Here are a few pretty amazing potential developments that are on the horizon.

Scientist working in a laboratory setting. Photo by Adam Bezer on Unsplash

1. Growing new teeth

Unlike sharks, humans are known to grow only two sets of teeth, our baby teeth and permanent adult teeth. If one gets knocked out or lost due to decay or infection, you're out of luck!

But researchers say growth buds exist in our gums for a third set, and scientists in Japan have had success in activating them to grow naturally. It could be a major gamechanger that could one day replace dentures and prosthetics. The team has moved onto human trials and has a target date of having a drug ready by 2030.

2. Cancer vaccines

Medical scientists have made amazing strides in cancer research, especially in the field of vaccines.

Did you know that lung cancer is considered to be the most deadly of the bunch? A lung cancer vaccine could be available very soon. If a cancer vaccine sounds odd, think of it this way: Cancer can be treated by chemotherapy and radiation, but there's always a chance of it coming back. People who have survived cancer could theoretically take the vaccine and massively improve their chances of reoccurrence.

A similar vaccine is showing promising results in clinical trials for pancreatic cancer.

3. Better treatment for Alzheimers

Alzheimer's Disease is one of the most destructive and heartbreaking conditions imaginable. It's also extremely difficult to treat, with most currently available therapies and medications focusing on slowing or temporarily relieving certain symptoms.

One new avenue scientists are exploring is a vaccine that could target a protein called tau, which clumps together and tangles up crucial neurofibers that deliver information in the brain. One such medication aims to activate a patient's immune system and produce "a strong antibody response against both pTau and its harmful aggregated form." The drug was recently fast-tracked by the FDA and has shown promising results in human clinical trials.

Another relatively new development is the availability of monoclonal antibody treatment, which helps slow the progression of the disease. Currently, the treatments are not particularly cost-effective but may become moreso in the near future.


smiling woman in gray cardigan Photo by Tatiana Zanon on Unsplash

4. Breakthrough treatment for Huntington's Disease

Huntington's is a fatal central nervous system disorder that shuts down key brain functions in patients like speech, walking, and cognitive function. Some of the symptoms can be treated but, so far, little can be done to slow or stop the progression of the disease.

However, a new drug known as PTC518 was recently fast-tracked by the FDA due to promising results in clinical trials. It attacks mutant Huntington protein in blood cells and in cerebrospinal fluid and has been shown to improve symptoms of the disease in a 12-month trial run. What's especially exciting is that this drug attacks the disease itself rather than just treating symptoms at the surface level.

5. Targeted viruses that kill antibiotic-resistant bacteria

Bacteria is getting smarter and evolving. Antimicrobial resistance is a grave threat to the global population as well-known antibiotics become less effective against infection and new antibiotics are expensive and difficult to develop.

(If you've ever dealt with a staph infection, you know how scary it is when drugs just... don't work.)

This is where special viruses, called bacteriophages or just phages, come into play. These viruses selectively target and kill bacteria, and were actually first used about 100 years ago. Scientist are coming around to using them again. In select settings, they've proven to be incredibly effective against resistant infections, but will need more testing before they become widely available. However, it's definitely possible that this become a viable alternative to antibiotics in some cases in the next few decades!

6. Synthetic and bioprinted organs


human heart Photo by camilo jimenez on Unsplash

There are simply not enough donor organs going around for all the people who need a healthy liver, heart, or kidney.

Luckily, incredible strides have been made in creating artificial organs that can function like the real thing. A man in Australia just lived for 100 days with a titanium heart while he awaited a transplant! And bioprinting technology – quite literally 3D printing using real tissue and living cells — has the potential to create new working organs from scratch in the near future. Genetically modifying animal organs to function in humans temporarily or maybe even permanently has also come an extremely long way and is a process that will drastically improve in the coming years.

7. A one-pill cure for Hepatitis B

Hepatitis B is a potentially fatal infection of the liver that affects hundreds of millions of people worldwide. There is a safe and effective vaccine available to some people, but it's only preventative and won't treat active infections.

A research team in Israel recently discovered that a low dose of well-known chemotherapy drug, Curaxin-137, completely destroyed a crucial and mysterious protein that the Hepatitis virus depends on. The testing was done in a lab setting, so the next step is clinical trials. The team hopes that one day in the not-so-distant future, patients could take a single dose and completely eradicate the virus in their system. That's about as close to a miracle-cure as you can get!

Not all of these potential breakthroughs will come to fruition, but it's pretty amazing to dig into the advancements and discoveries that are being made every day. This list is just scratching the surface, to say nothing of robotic surgeons that will make major surgeries less invasive, new treatments for baldness, nanotechnologies that can deliver medicine to specific parts of the body, and more. Ultimately, good news is coming relatively soon for people who need it.


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Strangers rally to cry for help for 22-year-old mother given just four months to live

In 24 hours, people flooded the family with donations to hopefully buy Rachael Burns some time with her 1-year-old daughter, Raeya.

www.gofundme.com

Rachael Burns was given a dire prognosis as her daughter turned one.

Being given just a few months to live is a daunting prognosis for anyone, but when you're a 22-year-old mother with a 1-year-old daughter, it's particularly tragic. Your adult life has just begun. You are the world to your young child. Your partner is suddenly looking at losing you and becoming a single parent, all in one fell swoop.

Rachael Burns of Belfast, Northern Ireland, is facing that exact reality. Eight months ago, she began experiencing headaches, dizzy spells, and irritation in her eyes, according to Belfast Live. At first, doctors chalked it up to dehydrated eyes and she considered them migraines, but after an emergency trip to the hospital in early June 2024, Burns was diagnosed with diffuse midline glioma brain tumor—brain cancer with a rare, aggressive mutation that is spreading down her spine.

Because of its size and where it's located, doctors said there is no way to even attempt an operation on it. Consultants told her that anyone who came in with her symptoms and that diagnosis generally had 9 to 12 months to live.

"I’ve shown symptoms for the last eight," Burns told Belfast Live. “I was told to assume that that was the case and try to make the most of the next four months.

“I left that appointment with no real hope and I didn’t know how to tell my mum and the rest of the family, I didn’t want them to get upset. It felt like everything had just been taken away from me at that point."

Facing such a dire prediction, Burns began writing years' worth of birthday cards for her daughter, Raeya, who just had her first birthday. The only option appeared to be six weeks of radiotherapy, which would do little to help.

But research into experimental therapies unveiled a ray of hope to buy more time with her family.

"We've identified a potentially life-extending treatment in Germany, under the name of ONC201," the family shared on GoFundMe, "but it comes at a significant cost. Should Rachael qualify, we need funds to pay for travel costs, accommodation and the drugs themselves.

"We refuse to let financial worries hinder Rachael's fight for her life or deprive her and her daughter of precious time together. Our goal is to ensure their comfort should the worst come to pass. No one should go from celebrating their child's first birthday to facing a terminal illness so swiftly."

Not only did the local community of West Belfast turn out for this young family but people around the world did as well. In less than 24 hours, they'd raised £30,000 (approximately $38,000 U.S.).

mom and dad holding baby in front of a birthday cake

Donate to Support a young mother battling terminal cancer, organized by Rachael Burns.

www.gofundme.com

“I’m just totally overwhelmed by the response that we have got so far,” Rachael said. “Belfast is such a small place but you never think that people from all over would show as much kindness as they have done for me and my family. It is a scary time to be going through all of this but this has given me more hope that I can spend some more time with my family.”

Burns told The Irish News that the treatment she's seeking in Germany has extended the life of people with her diagnosis by as much as 22 months. That may not sound like much time, but in the life of a small child, it's hugely significant.

“My Raeya will always know just how much her mummy fought with everything in her power for even a quick glimpse of watching her grow into the beautiful, strong and kind girl I know she will be in this world," Burns said. “Situations are what you make of them and I refuse to just be another statistic.”

While the future is uncertain for the Burns family, the money that's been raised gives her the best chance for a miracle. Any funds that don't go to Rachael's treatment will go into a bank account for young Raeya "to support her in life for if the time comes when she loses her mother."

As of December 2024, Rachael made an update to her GoFundMe to share that, miraculously, her most recent MRU showed that the tumor was stable and had not grown since her initial diagnosis. Even better, the cancer seems to have vanished from her spine:

"Hi everyone it’s Rachael, haven’t posted an update since July so thought I’d come on and let use know how I’m getting on. I had my most recent MRI at the end of October and I was very grateful to find out my tumour was stable and had not grown since my diagnosis in May. They also discovered the cancer seems to have disappeared from my spine which is incredible news.

After hearing I may of only made it to October and now being here for Christmas shows just how well I’ve been looked after, I want to thank you all for allowing me to have access to private health care and treatment. I’m still a bit wobbly but I’m now able to walk without assistance and make memories with my family and friends and I can’t thank you all enough for allowing me the opportunity for more time.

Hope you all have a wonderful Christmas, love Rachael x"
Woman holds baby

Rachael and Raeya at Christmastime

www.gofundme.com

Rachael and her family are still taking donations through their GoFundMe and have come close to their goal. Access it here and be sure to spread the word. Every little action counts.


This article originally appeared last year.

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'Princess Bride' star Mandy Patinkin shared a moving detail about the film with a grieving woman

Two souls connecting over the loss of their fathers. (Phew, grab a tissue for this one, folks.)

via Mandy Patinkin / TikTok

There was an emotional exchange on TikTok between two people who lost their fathers to cancer. One was actor Mandy Patinkin, the other was TikTok user AJ Webb.

Patinkin currently stars on The Good Fight, but one of his most famous roles is Inigo Montoya in the 1987 classicThe Princess Bride. In the film, Montoya is a swordsman who is obsessed with confronting a six-fingered man who killed his father.

Webb recently lost her father Dan to mantle cell lymphoma. She had heard a rumor that Patinkin used his father's death from cancer as motivation in a pivotal scene where he confronts the six-fingered Count Rugen (Christopher Guest) in a duel.

Rugen tells Montoya he will give him anything he wants after being bested by Montoya who passionately replies, "I want my father back, you son of a bitch."

@mandypatinktok @alaska_webb thank you for finding us and sharing this! ✨ Sending big love and light to you and yours. More in comments. #grieving #cancer #dads ♬ original sound - Mandy Patinkin and Kathryn G

Webb's father was a big fan of Montoya's performance in the film so she reached out to TikTok to learn if the rumor was true.

"I saw on the internet the rumor that when Mandy Patinkin said that line, he was thinking of his own father who had passed away from cancer," Webb said while crying. "And it was a very raw emotion. Ever since then, it's kind of really stuck with me."

Patinkin, who is a TikTok user, heard that the woman had reached out to him and he gave a heartfelt response.

"First of all, your dad is taking care of you," he said. "Secondly, it is true, 100% true. I went outside in this castle and walked around and I kept talking to my dad."

"The minute I read the script, I knew, I said to [my wife], I said, 'I'm going to do this part because in my mind, if I get the six-fingered guy, that means I killed the cancer that killed my dad and I'll get to visit my dad," he said.

"That moment was coming, and I went and I played that scene with Chris [Guest], and then I went back out there and talked to my dad," Patinkin said.

He then told Webb that she has the power to talk to her father, too.

"And so, you can talk to your dad anytime you want, anywhere you want," he said. "If you could somehow let me know your dad's name because I say prayers for anyone I've ever known. Now I feel like I know you, and therefore I know your dad, and I will list his name in my prayers every day, and they make me feel like they're with me, wherever I go, and I'd like your dad to hang out with me."

View Webb's heartwarmingly emotional response below:

@alaska_webb

Is this real life?! #mandypatinktok #princessbride #lgbtq #grief #millenial #imissmydad

This story originally appeared four years ago.

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Man honors mom's passing with a tattoo of her handwritten diary entry from the day he was born

"The second I saw it I thought to myself, 'Oh my god, these were her first thoughts about me.'"

Photos courtesy of Jake Bley

Jake Bley wanted to commemorate the 10th anniversary of his mother's passing.

When kids are growing up, they often see their mother in one dimension—just "Mom"—without much thought for the life she lived before kids or who she is outside of that role. It's usually not until we reach our own adulthood that we recognize, "OH, Mom is much more than just my mother," and if we're lucky, we then get to know her in a whole new light and celebrate all that she is.

Jake Bley is lucky to be getting to know and celebrate his mother, Nicki—but in a very different way than most people do. Nicki Bley was only 46 when she died after a year-long battle with Acute Myeloid Leukaemia in 2014. Jake, one of Nicki's five children, was in his early 20s when she passed.

toddler in mom's arms and adult son with arm around momJake as a toddler and as an adult with his mom, NickiPhotos courtesy of Jake Bley


"As a young mother, our relationship was closer to a friendship than a usual mother/son relationship," Jake tells Upworthy. "I could go to her about anything, and she was always supportive…she was one of my best friends."

woman bald from chemo laughing with her adult son

Jake and Nicki just months before Nicki passed

Photo courtesy of Jake Bley

Shortly before she died, Nicki gave each of her kids a special gift. To Jake, she handed over her collection of handwritten diaries she'd kept from the time she was 8 years old.

"When she gave each of her children our gifts she was very sick," he says. "But she told me she gave me the diaries and other sentimental items because she knew I would value them, and I could process her thoughts throughout the years. Get to really know who she was and value that. The good and the bad."

"It has been 10 years since she passed, and I only started really looking at the items recently," Jake shares. "It has been too hurtful to explore them until now. That's when I found the little red Collins from 1989, the year I was born. From there, I flicked to the day I was born and that was when I saw her entry—'only a little fellow.'"

Jake had been born prematurely, weighing only 5.7 pounds at birth, and Nicki had jotted "Only a little fellow" as a note beneath his statistics.

"The second I saw it I thought to myself, 'Oh my god, these were her first thoughts about me," Jake says. "I couldn't stop thinking about it."

As part of his healing journey, Jake decided to tattoo the phrase on his leg, in his mom's handwriting, to commemorate the 10th anniversary of her passing.

"I took the day off work, very nervous, and I walked into a local tattoo artist studio with no booking," he says. "Up until then I didn't feel like I could commit. My tattoo artist Riley was incredible. I told her the story, and she took the 1989 Red Collins diary and copied the handwriting on to a transfer for the tattoo."

"I love meaningful tattoos," she told him. It was Jake's first time getting a tattoo, but he says that all of his nerves instantly vanished when he saw the final product.

"It was perfect. I felt like a weight had been lifted off my shoulders, and it was a happy moment. When I got back to my car I cried happy tears, because for the first time in a very long time I was letting myself feel my emotions."

He shared a video documenting the tattoo experience on TikTok:

@jakebley

TW: GRIEF. I know shes watching over me. #Tattoo #Grief #griefjourney ❤️

Jake says his grief over his mother's death has been complex. "It's not until years later that I started to understand the impact of losing a parent, and the need to not only experience, but feel my emotions," he says. "Taking the time to rediscover my mother, and getting this tattoo a decade later has been part of my healing journey."

Jake's story has gone viral on social media, with people offering their words of comfort and their own experiences with remembering their loved ones, which has given a whole new dimension to Nicki's legacy.

"It has been so wonderful seeing the love pouring out from the community," Jake tells Upworthy. "The thought that 10 years on my mother's handwriting, love and memory not only lives on but is celebrated by so many truly fills my heart."


This article originally appeared in July.

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