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A female scientist’s discovery may lead to the first 'on-demand' male birth control pill

“Men need an option so that the burden of contraception is not on females anymore,” says Dr. Melanie Balbach.

birth control, makle contraception, male pill
via Free Images

Close up of a man taking a pill.

Even though men have condoms and vasectomies, throughout history, the burden of contraception has ultimately been felt by women because they bear the ultimate responsibility if they become pregnant. To maintain their reproductive freedom, women must take hormone-altering pills, wear patches or insert hormone-filled rings into their vaginas.

They also deal with copper IUDs, shots and spermicide-soaked sponges.

Women also have to manage the cost and hassle of doctors' visits to get their contraception and are at the mercy of the state if they have an unwanted pregnancy. Isn’t it time more men stepped up and took responsibility for contraception?

The good news is that new medical development may provide hope for the countless women who are tired of the pills, IUDs and headaches that come with female contraceptives. The cool thing is that a woman is behind its discovery.

A new pill developed by Weill Cornell Medicine could become the first “on-demand” male oral contraceptive. The drug has been found to stop sperm “in their tracks” and prevents pregnancies in preclinical models.

The pill is fast-acting and can have a man ready for sex 30 to 60 minutes before intercourse. That’s about as long as it takes for Viagra to work its magic.

"Our inhibitor works within 30 minutes to an hour," Dr. Melanie Balbach, a postdoctoral associate in their lab, said in a statement. "Every other experimental hormonal or nonhormonal male contraceptive takes weeks to bring sperm count down or render them unable to fertilize eggs."

The inhibitor was discovered by Dr. Balbach accidentally while working on a treatment for an eye condition. Dr. Balbach found that when mice took a drug that inactivates soluble adenylyl cyclase (sAC), they produced sperm that could not propel themselves through the vaginal tract.

Research shows that men who cannot produce sAC due to genetic mutations are infertile.

After the drug takes hold, the sperm are rendered useless for about 24 hours and then return to normal. So, the drug is not only fast acting but rapidly reversible.

“What I like about the proposed contraceptive in this study is the on-demand option,” says Ulrike Schimpf at the KTH Royal Institute of Technology in Sweden. “It would act rapidly, temporarily, and is efficient at the first dose.”

The discovery could be a sea change in how males approach contraception. But some are rightfully afraid that men may lie about taking the pill in the heat of the moment.

After all these years that women have had to bear the burden of responsibility, there’s something poignant about the first potential male contraceptive pill being discovered by a woman.

“We need more [birth control] options, and men need an option so that the burden of contraception is not on females anymore,” Balbach told New Scientist. “We’re very optimistic that once men take the inhibitor, it will have the same effect.”

Dr. Balbach and Dr. Jochen Buck, a professor of pharmacology at Weill Cornell Medicine, are currently working to develop a new version of the drug that lasts longer before testing it on humans. They hope to go to clinical trials by 2025.

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Cycle for Survival
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How can riding a bike help beat cancer? Just ask Reid Moritz, 10-year-old survivor and leader of his own “wolfpack”

Every year, Reid and his pack participate in Cycle for Survival to help raise money for the rare cancer research that’s helped him and so many others. You can too.

all photos courtesy of Reid Moritz

Together, let’s help fuel the next big breakthrough in cancer research

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There are many things that ten-year-old Reid Wolf Moritz loves. His family, making watches (yes, really), basketball, cars (especially Ferraris), collecting super, ultra-rare Pokémon cards…and putting the pedal to the medal at Cycle for Survival.

Cycle for Survival is the official rare cancer fundraising program of Memorial Sloan Kettering Cancer Center (MSK). One hundred percent of every dollar raised at Cycle for Survival events supports rare cancer research and lifesaving clinical trials at MSK.

At only two years old, Reid was diagnosed with pilocytic astrocytoma, a rare type of brain tumor.

Pediatric cancer research is severely underfunded. When standard treatments don't work, families rely on breakthrough clinical trials to give their children a real shot at long-term survival.

When Reid’s chemotherapy and brain surgery didn’t work, he was able to participate in one of MSK’s clinical trials, where he’s received some incredible results. “Memorial Sloan Kettering has done so much for me. It's just so nice how they did all this for me. They're just the best hospital ever,” Reid recalls.

And that’s why every year, you’ll find Reid with his team, aptly named Reid's Wolfpack, riding at Cycle for Survival. It’s just Reid’s way of paying it forward so that even more kids can have similar opportunities.

“I love sharing my story to inspire other kids to PERSEVERE, STAY STRONG and NEVER GIVE UP while also raising money for my amazing doctors and researchers to help other kids like me.”

Reid remembers the joy felt bouncing on his father’s shoulder and hearing the crowd cheer during his first Cycle for Survival ride. As he can attest, each fundraising event feels more like a party, with plenty of dancing, singing and celebrating.

Hoping to spread more of that positivity, Reid and his family started the Cycle for Survival team, Reid’s Wolfpack, which has raised close to $750,000 over the past eight years. All that money goes directly to Reid’s Neuro-Oncology team at Memorial Sloan Kettering.

In addition to cheering on participants and raising good vibes at Cycle for Survival events, Reid even designs some pretty epic looking merch—like basketball shorts, jerseys, and hoodies—to help raise money.

If you’re looking to help kids just like Reid, and have a ton of fun doing it, you’re in luck. Cycle for Survival events are held at Equinox locations nationwide, and welcome experienced riders and complete newbies alike. You can even join Reid and his Wolfpack in select cities!

And if cycling in any form isn’t your thing, a little donation really does go a long way.

Together, let’s help fuel the next big breakthrough in cancer research. Find out more information by checking out cycleforsurvival.org or filling out this interest form.

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Why didn't people smile in old photographs? It wasn't just about the long exposure times.

People blame these serious expressions on how long they had to sit for a photo, but that's not the whole picture.

Public domain images

Photos from the 1800s were so serious.

If you've ever perused photographs from the 19th and early 20th century, you've likely noticed how serious everyone looked. If there's a hint of a smile at all, it's oh-so-slight, but more often than not, our ancestors looked like they were sitting for a sepia-toned mug shot or being held for ransom or something. Why didn't people smile in photographs? Was life just so hard back then that nobody smiled? Were dour, sour expressions just the norm?

Most often, people's serious faces in old photographs are blamed on the long exposure time of early cameras, and that's true. Taking a photo was not an instant event like it is now; people had to sit still for many minutes in the 1800s to have their photo taken.

Ever try holding a smile for only one full minute? It's surprisingly difficult and very quickly becomes unnatural. A smile is a quick reaction, not a constant state of expression. Even people we think of as "smiley" aren't toting around full-toothed smiles for minutes on end. When you had to be still for several minutes to get your photo taken, there was just no way you were going to hold a smile for that long.

But there are other reasons besides long exposure times that people didn't smile in early photographs.

1800s photographsWhy so serious? Public domain

The non-smiling precedent had already been set by centuries of painted portraits

The long exposure times for early photos may have contributed to serious facial expressions, but so did the painted portraits that came before them. Look at all of the portraits of famous people throughout history prior to cameras. Sitting to be painted took hours, so smiling was out of the question. Other than the smallest of lip curls like the Mona Lisa, people didn't smile for painted portraits, so why would people suddenly think it normal to flash their pearly whites (which were not at all pearly white back then) for a photographed one? It simply wasn't how it was done.

A smirk? Sometimes. A full-on smile? Practically never.

"Mona Lisa" by Leonardo da Vinci, painted in 1503Public domain

Smiling usually indicated that you were a fool or a drunkard

Our perceptions of smiling have changed dramatically since the 1800s. In explaining why smiling was considered taboo in portraits and early photos, art historian Nicholas Jeeves wrote in Public Domain Review:

"Smiling also has a large number of discrete cultural and historical significances, few of them in line with our modern perceptions of it being a physical signal of warmth, enjoyment, or indeed of happiness. By the 17th century in Europe it was a well-established fact that the only people who smiled broadly, in life and in art, were the poor, the lewd, the drunk, the innocent, and the entertainment […] Showing the teeth was for the upper classes a more-or-less formal breach of etiquette."

"Malle Babbe" by Frans Hals, sometime between 1640 and 1646Public domain

In other words, to the Western sensibility, smiling was seen as undignified. If a painter did put a smile on the subject of a portrait, it was a notable departure from the norm, a deliberate stylistic choice that conveyed something about the artist or the subject.

Even the artists who attempted it had less-than-ideal results. It turns out that smiling is such a lively, fleeting expression that the artistically static nature of painted portraits didn't lend itself well to showcasing it. Paintings that did have subjects smiling made them look weird or disturbing or drunk. Simply put, painting a genuine, natural smile didn't work well in portraits of old.

As a result, the perception that smiling was an indication of lewdness or impropriety stuck for quite a while, even after Kodak created snapshot cameras that didn't have the long exposure time problem. Even happy occasions had people nary a hint of joy in the photographs that documented them.

wedding party photoEven wedding party photos didn't appear to be joyful occasions.Wikimedia Commons

Then along came movies, which may have changed the whole picture

So how did we end up coming around to grinning ear to ear for photos? Interestingly enough, it may have been the advent of motion pictures that pushed us towards smiling being the norm.

Photos could have captured people's natural smiles earlier—we had the technology for taking instant photos—but culturally, smiling wasn't widely favored for photos until the 1920s. One theory about that timing is that the explosion of movies enabled us to see emotions of all kinds playing out on screen, documenting the fleeting expressions that portraits had failed to capture. Culturally, it became normalized to capture, display and see all kind of emotions on people's faces. As we got more used to that, photo portraits began portraying people in a range of expression rather than trying to create a neutral image of a person's face.

Changing our own perceptions of old photo portraits to view them as neutral rather than grumpy or serious can help us remember that people back then were not a bunch of sourpusses, but people who experienced as wide a range of emotion as we do, including joy and mirth. Unfortunately, we just rarely get to see them in that state before the 1920s.

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Kids

Toddler's unbridled joy at seeing Target Christmas decor is pure holiday magic

He's in the "wow" phase 🥲


@vita.pasker/TikTok

May we all find something that makes us say "wow!" like this toddler.

It seems like even the most bah humbugiest of us are in the mood to be injected with a bit of Christmas cheer this year. And this video of a mom whisking her precious toddler through a holiday decor-filled Target can do just that.

Victoria Paskar had previously taken her son Ellis to Target when he was a newborn and unable to really understand or appreciate the festive hoopla happening all around him.

But this time, Ellis is a toddler. And in full toddler fashion, he is in complete and utter awe—and able to express it all in real time.

Paskar caught the whole adorable moment on camera as Ellis, from his shopping cart seat, kept shouting “Oh, wow! Wow!” in total amazement of the countless lit-up trees and aisle lines with elaborate decorations and colorful toys.

It’s just so magical and pure in every way. Truly the only thing that would have made it better would be “What’s This?” from Nightmare Before Christmas playing in the background.

Watch:


@vita.paskar This is when things start to get exciting 🥹 when they begin to understand! #fyp #christmas #target #toddler ♬ Rockin' Around The Christmas Tree - Brenda Lee

“Pov: your child’s second Christmas isn’t as a newborn anymore, but as a toddler,” Paskar wrote for her video’s caption, perfectly encapsulating that wonderful shift that happens when kids are old enough to take in the world around them, but young enough for even the littlest things to seem miraculous and exciting.

As that sense of wonder tends to begin waning around the age of six, it’s a fleeting moment worth cherishing. Other parents who watched the video certainly seemed to think so.

“Experiencing Christmas through your children's eyes is the BEST gift as parent can get!” one person wrote.

Another said, “My fave toddler phase is the ‘wow’ phase. They say ‘wow at everything!!”

Still another shared, “that’s my toddler too and I’m soaking it all up.”

As the holiday season approaches, let this heartwarming story serve as a reminder to try to see the world through a child’s eyes—inviting back in our own sense of wonder that turns even the littlest things into pure magic. It is, after all, part of what makes Christmas so special in the first place.

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Culture

People from other countries share 14 'obvious' signs that someone is an American

"Americans lean on anything they can while standing around…"

via zoetnet/Flickr, Ewen Roberts/Flickr and Tom Hodgkinson/Flickr

Some American tourists enjoying the sights

Americans have a style and personality all their own, which isn’t a bad thing. It’s just noticeable when they travel aboard. Americans often stand out because of their outgoing personalities. They are friendly and enjoy having casual conversations with strangers.

This is an endearing trait to a lot of people in more reserved cultures, although it can also come off as a little brash.

An American characteristic that isn’t quite endearing to people in other countries is that they can be rather loud. In Europe, one can always notice the Americans in the restaurant because they can be heard from across the room.

A Reddit user named Frosty-Ad3575 wanted to know the specific ways that Americans stand out when traveling abroad, so they asked the AskReddit subforum: “What’s an obvious sign that someone is an American?”

The post was popular, receiving nearly 6,000 responses in just 6 days. The most popular ones described how Americans' unique personalities, style of dress, dental hygiene and body language make them easy to spot.

Here are 14 “obvious” signs that someone is an American.

1. Posture

"Apparently, the CIA trains American agents to not lean on things if they go undercover in foreign countries because Americans lean on anything they can while standing around." — Clown1998

"I bet MI6 trains British agents to lean on everything if they go undercover in America because Americans lean on anything they can while standing around." — KingoftheMongoose

2. The date

"MMDDYYYY." — LowRevolution6175

3. Distances are different

"Anything under 4 hours is 'close by.'" — Grey-Canary

"Everything in Europe is around the corner if you're from the US. I can drive the whole day and not leave my state, but in Europe, I can pass through 4 countries in that same time frame." — JayHitter

4. They're polite to servers

"In the touristy cafe-restaurant I worked at:

If they asked me for the nicest spot we had

If they asked me my recommendation without seeing the menu first

I would walk to the table, and they would say right away ‘hey, how are you doing?’ This one threw me off a lot at first. Why is this person asking me how I'm doing?? I'm just there to take the order. I got used to it, and I think they found my awkwardness cute.

They would ask my name when I greeted them and took their order.

I'm Northern European." — Muc_99

"It’s under-appreciated just how polite, friendly, and sincere Americans are in general. It blew my mind the first time I came to the US, and I love that my children are growing up with those same values." — Irishweather5000


5. The water bottles

"I was told, 'Americans carry water bottles around like they're worried they'll never have access to clean water ever again.'" — Kosher_Dill

"I don't care what anyone says. If you think carrying a water bottle when walking a lot is weird, you're probably slightly dehydrated all the time and are just desensitized to it. You seriously need to drink water frequently if you want to be ideally healthy." — Tan11

6. Smiling

"I was in Germany this past summer, and I realized smiling at everyone you make eye contact with is very American. When I went to London on the same trip, they seemed less weirded out by it but would awkwardly return the smile. I was taught to always start with a disarming smile. Never realized it was American." — 12ozFitz

7. "More ice, please."

"I spent a year in Europe completely iceless to the point I forgot that was a thing. I stopped at a bar in Chicago fresh off the plane and not only did I get free tap water, but water with ice. I instantly felt at home." — Outside-Crezz8119

8. Personal space

"As an American man, I’ve been told repeatedly by European and Asian friends that we simply take up space (not by being fat) as though we’re entitled to it. Men in other countries apparently don’t claim the same personal space we do." — Potomacan

9. White teeth

"It’s even more bizarre that they assume we have braces or bleach our teeth because they’re straight and white. I have naturally straight white teeth. I brush them twice a day so they stay white. I don’t do anything special to them, but I remember being in London and some similar-aged students literally making fun of me for my teeth… it’s true that they don’t naturally look like headstones in an ancient graveyard, but there’s no need to make fun." — DPretilloZbornak

10. Casual dress

"My friend went to Germany recently, and what people said about Americans is you can spot them a mile away because they’re the ones wearing pajamas in public. Apparently, in other countries, at least Germany, they dress a little more formally and in less baggy clothes than we do in America." — MarcusWahlbezius

11. Baseball hats

"Baseball cap... even on an infant riding in a pram." — SyntheticOne

12. Shoes

"Americans are shoe snobs (they don’t think they are, but they are). Setting aside wealthier business types, Americans generally wear more on-brand, on-trend, high-quality shoes than others." — Mouflony

13. They're loud

"That was my first thought. Americans yell at each other in normal conversation in public. I noticed it years ago in Europe, and now I can’t stand it in the US." — SucccotashOther277

14. Occupation matters

"Immediately asking someone what they do for a living when meeting them. Our jobs and work are our entire identity." — Bealzu

"I hate that about American culture. I'm an American and recently became a SAHM, so I don't have an answer to 'What do you do for a living?' Half the time, I add the caveat, ‘Oh, my last job was with Apple,’ so that I'm not written off as an unemployed ‘loser.’ But it really is dumb to determine a person's worth by what they do in order to afford food and shelter." — WassupSassySasquatch


This article originally appeared in January.

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Adopted man does DNA test and finds biological mom in a very familiar place

They had interacted in the past and had no idea they were related.

via ABC 7/YouTube

Lenore LIndsey and Vamarr Hunter.

At the age of 35, Vamarr Hunter, now 50, learned that he was put up for adoption as a newborn. Two years ago, he saw a television show about genealogy and did a DNA test to try and find his biological family.

The genealogist quickly determined that Lenore Lindsey, 67, owner of “Give Me Some Sugah” Bakery in South Shore in Chicago, was Hunter’s mother, so she gave her Hunter’s number. Lindsey had given him up for adoption when she was 17 years old and she was hesitant about contacting him.

“I was on the phone talking to my friend when a call came through from the bakery. I was like, ‘Why is Give Me Some Sugah’ calling me?’” Hunter told the Washington Post about when he got the call from Lindsey in the spring of 2022.

The incredible thing was that Hunter lived near the bakery and visited it weekly. “We had an immediate connection. All the pieces had fallen into place,” Lindsey said.

- YouTubewww.youtube.com

The life-changing news came after a recent breast cancer surgery and Lindsey was preparing to undergo chemotherapy. Hunter immediately started calling her “mother” or “ma” and went with her to chemotherapy appointments. While Lindsey recovered, Hunter stepped in, managing the bakery. After Lindsey suffered a stroke, he quit his job to run it full-time.

After retiring from her career as an accountant in 2008, Lindsey opened “Give Me Some Sugah” to provide a positive place for people in the community to relax and enjoy sweet treats. “I just wanted to have a nice little neighborhood place where people didn’t have to be served through bulletproof glass, and they could be treated like people,” she told the Chicago Sun-Times.



By reconnecting with his mother, Hunter met a host of new relatives, and Lindsey became a grandmother to Hunter's 4 kids.

Lindsey has a daughter named Rachel, 40, who believes Hunter fits perfectly into the family. “He talks like he was raised in the house with us,” Lindsey said, according to the New York Post. “We’re both the same.”

The reconnection between mother and child must have brought a lot of closure to Lindsey, who never saw his face when he was born out of fear she’d become too attached. But her mother got a good look at him, saying that he was “beautiful.”

Hunter doesn’t have any regrets about how things went in the past. He’s just happy to be part of a family where he feels he belongs. “You can't make up for time and days gone by. What you can do is properly utilize the time that you have,” he said, according to People.

Having a new son has been an unexpected blessing in Lindsey’s golden years. “It's the most joyful story and time in my life," Lindsey said. “In my senior years, all of this has come together.”

Lindsey is proud of the man Hunter has become. “He really is such a good soul. He has just no animosity [about being given up for adoption]. I’m sure he’s adding years to my life because I just got this sense of peace. It’s like your life came full circle,” said Lindsey.

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Brit shares the one-word 'dead giveaway' that American actors are doing an English accent

There's one word they never get right.

via Warner Bros Discovery

Peter Dinklage on "Game of Thrones?

When it comes to actors doing accents across the pond, some Americans are known for their great British accents, such as Natalie Portman ("The Other Boleyn Girl"), Robert Downey, Jr. ("Sherlock Homes"), and Meryl Streep ("The Iron Lady").

Some have taken a lot of heat for their cartoonish or just plain weird-sounding British accents, Dick Van Dyke ("Mary Poppins"), Kevin Costner ("Robin Hood: Prince of Thieves") and Keanu Reeves ("Bram Stoker's Dracula").

Some actors, such as Tom Hardy (“The Drop”) and Hugh Laurie (“House”), have American accents so good that people have no idea they are British.

Benedict Townsend, a London-based comedian and host of the “Scroll Deep” podcast, says there is one word that American actors playing characters with a British accent never get right. And no, it’s not the word “Schedule,” which British people pronounce the entire first 3 letters, and Americans boil down to 2. And it’s not “aluminum,” which British and American people seem to pronounce every stinking letter differently.

@benedicttown

The one word American actors aways get wrong when doing an English accent

What word do American actors always get wrong when they do British accents?

“There is one word that is a dead giveaway that an English character in a movie or a TV show is being played by an American. One word that always trips them up. And once you notice it, you can't stop noticing it,” Townsend says. “You would see this lot in ‘Game of Thrones’ and the word that would always trip them up was ‘daughter.’”

Townsend adds that when British people say “daughter,” they pronounce it like the word “door” or “door-tah.” Meanwhile, Americans, even when they are putting on a British accent, say it like “dah-ter.”

“So top tip if you are an actor trying to do an English accent, daughter like a door. Like you're opening a door,” Townsend says.



What word do British actors always get wrong when doing American accents?

Some American commenters returned the favor by sharing the word that British actors never get right when using American accents: “Anything.”

"I can always tell a Brit playing an American by the word anything. An American would say en-ee-thing. Brits say it ena-thing,” Dreaming_of_Gaea wrote. "The dead giveaway for English people playing Americans: ‘Anything.’ Brits always say ‘EH-nuh-thin,’” marliemagill added.

"I can always tell an actor is English playing an American when they say ‘anything.’ English people always say it like ‘enny-thin,’” mkmason wrote.



What is the cot-caught merger?

One commenter noted that the problem goes back to the cot-caught merger, when Americans in the western US and Canadians began to merge different sounds into one. People on the East Coast and in Britain pronounce them as different sounds.

“Depending on where you live, you might be thinking one of two things right now: Of course, ‘cot’ and ‘caught’ sound exactly the same! or There’s no way that ‘cot’ and ‘caught’ sound the same!” Laura McGrath writes at DoYouReadMe. “As a result, although the different spellings remain, the vowel sounds in the words cot/caught, nod/gnawed, stock/stalk are identical for some English speakers and not for others.”

American actors owe Townsend a debt of gratitude for pointing out the one thing that even the best can’t seem to get right. He should also give the commenters a tip of the cap for sharing the big word that British people have trouble with when doing an American accent. Now, if we could just get through to Ewan McGregor and tell him that even though he is fantastic in so many films, his American accent still needs a lot of work.

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