+
“A balm for the soul”
  review on Goodreads
GOOD PEOPLE Book
upworthy
Innovation

For the first time ever, a 13-year-old boy has been cured of a deadly brain cancer

The boy’s tumor disappeared after participating in a new clinical trial.

Boy who was cured of cancer posing with family for Christmas photos
Lucas Jemeljanova, then aged 5, with his parents and sister a year before he was diagnosed with DIPG. (via Facebook)

Lucas Jemeljanova poses with his family a year before being diagnosed with cancer (Facebook)

(This article originally appeared on 6.25.24)


Few things strike fear in the heart of parents and doctors more than a cancer called diffuse intrinsic pontine glioma, or DIPG. Primarily found in children, DIPG is a highly aggressive brain tumor that is uniformly fatal, with less than 10 percent of children surviving longer than two years after diagnosis.

But for the first time ever, a 13-year-old boy from Belgium named Lucas Jemeljanova has beaten the odds.

Diagnosed with DIPG at age six, Lucas’ doctor Jacques Grill told Lucas’ parents, Cedric and Olesja, that he was unlikely to live very long. Instead of giving up hope, Cedric and Olesja flew Lucas to France to participate in a clinical trial called BIOMEDE, which tested new potential drugs against DIPG.

Lucas was randomly assigned everolimus in the clinical trial, a chemotherapy drug that works by blocking a protein called mTOR. mTOR helps cancer cells divide and grow new blood vessels, while everolimus decreases blood supply to the tumor cells and stops cancer cells from reproducing. Everolimus, a tablet that’s taken once per day, has been approved in the UK and the US to treat cancers in the breast, kidneys, stomach, pancreas, and others—but until the BIOMEDE clinical trial, it had never before been used to treat DIPG.

Lucas Jemeljanova poses with his motherLucas Jemeljanova poses with his mother(lesja Jemeljanova / Facebook)

Though doctors weren’t sure how Lucas would react to the medication, it quickly became clear that the results were good.

“Over a series of MRI scans, I watched as the tumor completely disappeared,” Grill said in an interview. Even more remarkably, the tumor has not returned since. Lucas, who is now thirteen, is considered officially cured of DIPG.

Even after the tumor was gone, Grill, who is the head of the Brain Tumor Program in the Department of Child and Teenage Oncology at Gustave Roussy cancer research hospital in Paris, was reluctant to stop Lucas’ treatments. Until about a year and a half ago, Lucas was still taking everolimus once every day.

“I didn’t know when to stop, or how, because there was no other reference in the world,” Grill said.

While Lucas is the only one in the clinical trial whose tumor has completely disappeared, seven other children have been considered “long responders” to everolimus, meaning their tumors have not progressed for more than three years after starting treatment.

Lucas Jemeljanova poses with his mother to mark cancer awareness monthLucas Jemeljanova with his mother (Facebook)(lesja Jemeljanova / Facebook)

So why did everolimus work so well for Lucas? Doctors think that an extremely rare genetic mutation in Lucas’ tumor “made its cells far more sensitive to the drug,” Grill said, while the drug worked well in other children because of the “biological peculiarities” of their tumors.

While everolimus is by no means a cure, the trial has provided real hope for parents and families of children diagnosed with DIPG. Doctors must now work to better understand why Lucas’ tumor responded so well to the drug and how they can replicate those results in tumor “organoids”—artificially-grown cells that resemble an organ. After that, said Marie-Anne Debily, a researcher in the BIOMEDE trial, “the next step will be to find a drug that works as well on tumor cells.”

In the meantime, however, Lucas’ doctors are thrilled.

“Lucas’ case offers real hope,” said Debily.


Lucas Jemeljanova poses with his familyLucas Jemeljanova with his parents and sister(lesja Jemeljanova / Facebook)

From Your Site Articles
Badge
Cycle for Survival
Cycle for Survival
Sponsored

How can riding a bike help beat cancer? Just ask Reid Moritz, 10-year-old survivor and leader of his own “wolfpack”

Every year, Reid and his pack participate in Cycle for Survival to help raise money for the rare cancer research that’s helped him and so many others. You can too.

all photos courtesy of Reid Moritz

Together, let’s help fuel the next big breakthrough in cancer research

True

There are many things that ten-year-old Reid Wolf Moritz loves. His family, making watches (yes, really), basketball, cars (especially Ferraris), collecting super, ultra-rare Pokémon cards…and putting the pedal to the medal at Cycle for Survival.

Cycle for Survival is the official rare cancer fundraising program of Memorial Sloan Kettering Cancer Center (MSK). One hundred percent of every dollar raised at Cycle for Survival events supports rare cancer research and lifesaving clinical trials at MSK.

At only two years old, Reid was diagnosed with pilocytic astrocytoma, a rare type of brain tumor.

Pediatric cancer research is severely underfunded. When standard treatments don't work, families rely on breakthrough clinical trials to give their children a real shot at long-term survival.

When Reid’s chemotherapy and brain surgery didn’t work, he was able to participate in one of MSK’s clinical trials, where he’s received some incredible results. “Memorial Sloan Kettering has done so much for me. It's just so nice how they did all this for me. They're just the best hospital ever,” Reid recalls.

And that’s why every year, you’ll find Reid with his team, aptly named Reid's Wolfpack, riding at Cycle for Survival. It’s just Reid’s way of paying it forward so that even more kids can have similar opportunities.

“I love sharing my story to inspire other kids to PERSEVERE, STAY STRONG and NEVER GIVE UP while also raising money for my amazing doctors and researchers to help other kids like me.”

Reid remembers the joy felt bouncing on his father’s shoulder and hearing the crowd cheer during his first Cycle for Survival ride. As he can attest, each fundraising event feels more like a party, with plenty of dancing, singing and celebrating.

Hoping to spread more of that positivity, Reid and his family started the Cycle for Survival team, Reid’s Wolfpack, which has raised close to $750,000 over the past eight years. All that money goes directly to Reid’s Neuro-Oncology team at Memorial Sloan Kettering.

In addition to cheering on participants and raising good vibes at Cycle for Survival events, Reid even designs some pretty epic looking merch—like basketball shorts, jerseys, and hoodies—to help raise money.

If you’re looking to help kids just like Reid, and have a ton of fun doing it, you’re in luck. Cycle for Survival events are held at Equinox locations nationwide, and welcome experienced riders and complete newbies alike. You can even join Reid and his Wolfpack in select cities!

And if cycling in any form isn’t your thing, a little donation really does go a long way.

Together, let’s help fuel the next big breakthrough in cancer research. Find out more information by checking out cycleforsurvival.org or filling out this interest form.

From Your Site Articles
best of humanity
Education

Why didn't people smile in old photographs? It wasn't just about the long exposure times.

People blame these serious expressions on how long they had to sit for a photo, but that's not the whole picture.

Public domain images

Photos from the 1800s were so serious.

If you've ever perused photographs from the 19th and early 20th century, you've likely noticed how serious everyone looked. If there's a hint of a smile at all, it's oh-so-slight, but more often than not, our ancestors looked like they were sitting for a sepia-toned mug shot or being held for ransom or something. Why didn't people smile in photographs? Was life just so hard back then that nobody smiled? Were dour, sour expressions just the norm?

Most often, people's serious faces in old photographs are blamed on the long exposure time of early cameras, and that's true. Taking a photo was not an instant event like it is now; people had to sit still for many minutes in the 1800s to have their photo taken.

Ever try holding a smile for only one full minute? It's surprisingly difficult and very quickly becomes unnatural. A smile is a quick reaction, not a constant state of expression. Even people we think of as "smiley" aren't toting around full-toothed smiles for minutes on end. When you had to be still for several minutes to get your photo taken, there was just no way you were going to hold a smile for that long.

But there are other reasons besides long exposure times that people didn't smile in early photographs.

1800s photographsWhy so serious? Public domain

The non-smiling precedent had already been set by centuries of painted portraits

The long exposure times for early photos may have contributed to serious facial expressions, but so did the painted portraits that came before them. Look at all of the portraits of famous people throughout history prior to cameras. Sitting to be painted took hours, so smiling was out of the question. Other than the smallest of lip curls like the Mona Lisa, people didn't smile for painted portraits, so why would people suddenly think it normal to flash their pearly whites (which were not at all pearly white back then) for a photographed one? It simply wasn't how it was done.

A smirk? Sometimes. A full-on smile? Practically never.

"Mona Lisa" by Leonardo da Vinci, painted in 1503Public domain

Smiling usually indicated that you were a fool or a drunkard

Our perceptions of smiling have changed dramatically since the 1800s. In explaining why smiling was considered taboo in portraits and early photos, art historian Nicholas Jeeves wrote in Public Domain Review:

"Smiling also has a large number of discrete cultural and historical significances, few of them in line with our modern perceptions of it being a physical signal of warmth, enjoyment, or indeed of happiness. By the 17th century in Europe it was a well-established fact that the only people who smiled broadly, in life and in art, were the poor, the lewd, the drunk, the innocent, and the entertainment […] Showing the teeth was for the upper classes a more-or-less formal breach of etiquette."

"Malle Babbe" by Frans Hals, sometime between 1640 and 1646Public domain

In other words, to the Western sensibility, smiling was seen as undignified. If a painter did put a smile on the subject of a portrait, it was a notable departure from the norm, a deliberate stylistic choice that conveyed something about the artist or the subject.

Even the artists who attempted it had less-than-ideal results. It turns out that smiling is such a lively, fleeting expression that the artistically static nature of painted portraits didn't lend itself well to showcasing it. Paintings that did have subjects smiling made them look weird or disturbing or drunk. Simply put, painting a genuine, natural smile didn't work well in portraits of old.

As a result, the perception that smiling was an indication of lewdness or impropriety stuck for quite a while, even after Kodak created snapshot cameras that didn't have the long exposure time problem. Even happy occasions had people nary a hint of joy in the photographs that documented them.

wedding party photoEven wedding party photos didn't appear to be joyful occasions.Wikimedia Commons

Then along came movies, which may have changed the whole picture

So how did we end up coming around to grinning ear to ear for photos? Interestingly enough, it may have been the advent of motion pictures that pushed us towards smiling being the norm.

Photos could have captured people's natural smiles earlier—we had the technology for taking instant photos—but culturally, smiling wasn't widely favored for photos until the 1920s. One theory about that timing is that the explosion of movies enabled us to see emotions of all kinds playing out on screen, documenting the fleeting expressions that portraits had failed to capture. Culturally, it became normalized to capture, display and see all kind of emotions on people's faces. As we got more used to that, photo portraits began portraying people in a range of expression rather than trying to create a neutral image of a person's face.

Changing our own perceptions of old photo portraits to view them as neutral rather than grumpy or serious can help us remember that people back then were not a bunch of sourpusses, but people who experienced as wide a range of emotion as we do, including joy and mirth. Unfortunately, we just rarely get to see them in that state before the 1920s.

From Your Site Articles
history
Family

Family health worker has a dire warning for parents who share photos of their kids online

She breaks down the case like a lawyer.

via Ruth Watts (used with permission) and Canva/Photos

A mother takes a photo of her child for her Instagram feed.

A recent study by Data Recovery found that 68% of parents admit to making posts and sharing photos about their children, and 73% of people don’t personally know everyone who looks at their page. This can be a big problem. While most parents think that “sharenting” is harmless, some real dangers can happen to children whose photos are shared online.

Should parents post photos of their kids online?

According to NPR, sharing photos of your children could result in them being bullied by other children, or they could have their photos digitally “kidnapped” and used by fake accounts. In some cases, the photos could wind up on child pornography sites.

Ruth Watts (@ruthwattshv on TikTok), a British family health worker, recently posted a viral TikTok about parents who overshare about their kids and she makes a point that everyone should hear. After scrolling through a typical parent's page, anyone can learn more about a child’s life than the parents would ever intend to share.

Watts says that by knowing a child only through social media, she can figure out their full name, date of birth, parents' names, birthday, where they live, the foods they like and dislike, the toys they play with, their diagnosis, the parks where they like to play and so much more.

@ruthwattshv

What’s your opinion on this? Let me know in the comments ❤️ #parenting #parentsoftiktok #parentingtips #mumsoftiktok #mumlife #mum #healthvisitor #responsiveparenting #gentleparenting #parentingtips #parentingrules #babytok #babyhacksandtips #gentleparentingtips #wholesomemomcontent #mumcontent #momcontentcreator #healthvisitor

We may not think we’re giving out much information about our children. Still, when you add up all the posts year after year, plus the comments, it would be pretty easy for a predator to learn a lot about a child based solely on social media posts.

“Can you guess how I know this child? I purely know them through watching them on social media,” Watts says in a video with over 500,000 views. “I purely know all of your information because the parents have chosen to share that private, confidential information about their child. And yes, a story here, a story there and upload here and upload there. It all creates a picture. It is a jigsaw that people notice. People pay attention to and the wrong people pay attention to.”

Watts also adds that when parents share pictures of children online, they put their children in a vulnerable position without asking for their consent. The video inspired over 500 comments, many from parents who thanked her for her brutal honesty and others who shared why they don’t share photos of their children online.

sharenting, parenting, kids onlineA mother takes a photo of her child for her Instagram feed. via Canva/Photos

“This is exactly why the majority of people have no idea I even have a child. The people that matter will see him grow up in person, not fake friends through a screen,” Mikita Blackmore wrote. “This is why I don’t post my daughter on social media; it’s so scary what people can do these days,” Clara Marie added.

“I always say if you wouldn’t go to the effort of printing the photo and handing it to that person, then they shouldn’t have access to that image,” Soph wrote.

Why shouldn't parents post photos of their kids online?

Watts says she created the video because she has 2 children and feels that kids everywhere deserve a voice. “I feel it’s important to advocate for children who are vulnerable and unable to consent to posting the images. Let alone the parents and children having no understanding of internet risks and security,” she told Upworthy. “How would people feel if I started posting pictures of them without consent? I’m sure they wouldn’t like it. So why is it ok for us to post our children?”

You can follow Watts on Instagram @RuthWattshv.

From Your Site Articles
social media
Modern Families

Woman goes to huge lengths to adopt husband's ex-wife's baby to save him from foster care

She had lived in foster care and didn't want it for the newborn with no name.

via Christie Werts/TikTok and Christie Werts/TikTok

Christie Werts and her son, Levi

Christie and Wesley Werts have taken the idea of a blended family to the next level. When the couple fell in love five years ago and married, they brought together her children, Megan and Vance, and his children, Austin and Dakota.

As of January, the Ohio family has five children after adopting young Levi, 2. Levi is the son of Wesley’s ex-wife, who passed away four days after the child was born. The ex-wife had the boy prematurely, at 33 weeks, and died soon after from drug addiction and complications of COVID-19.

When Levi was born, he was a ward of the state with no first name or birth certificate.

“When I heard about Levi, without hesitation, I said we should take him,” Christie said, according to The Daily Mail, and her reason went far beyond the fact that the child was the half-brother to two of her recently adopted children. “I myself was a foster kid and, although for the most part, I had a great experience, I did not want him going to foster care,” Christie said.

@cjthemom5

Replying to @Journey♥️ Yes, they will always know of her and ill be there for every emotion good or bad. But im also mom, ive been to every game, every doctors appt, sat with them if they needed an ear loved unconditional . I am mom also. #adoption #srorytime #siblings #foryou #loveislove

Before the family knew of Levi’s birth, Christie had a recurring dream about a blue-eyed, blonde-haired boy.

"Before Levi, we had wanted to try to have a child of our own," she told Newsweek. "I'm in my forties, so we knew that we would probably need fertility treatment, so I thought let's just think about it and what will be will be."

The problem was that Levi was in Texas, so the family sold their house and moved to the Lone Star State to go through the arduous adoption process. The situation was further complicated because Levi’s biological father had parental rights even though he had substance abuse problems. The family couldn’t move out of Texas until his rights were legally terminated.

But after a 16-month process, in January 2023, Levi became a legal family member. Christie understands that adopting her husband’s ex-wife’s baby may seem unusual to some people. "It's a lot to process for a lot of people, but honestly, it seems a lot crazier than it was. At the time, it just made sense," she said.

@cjthemom5

Our adoption is official !!! after 17 months!!! #adoption #son #loveyou #ourstory#foryou #fyp

Even though Christie knew in her heart that she must adopt Levi, she wasn’t without reservations. “'If I said I did not [have concerns beforehand], that would not be honest,” she told The Daily Mail. “This was different—I was going to walk into a child I never met and was worried the circumstances would hinder this instant love. But [...] he stole my heart. I also felt this intense need to protect him.”

These days, Levi fits right in with the family, and the rest of the kids are happy to be back to living an everyday life without any caseworkers or inspections.

“He's great, he is the king of the house! We are all very close. He won't understand the journey right now, but someday, I will let him know we fought for him!” Christie said.


This article originally appeared 1 year ago.

From Your Site Articles
adoption
Health

Here's the big reason why you're probably feeling bored all the time

There's a strange connection between overstimulation and chronic boredom.

via Canva/Photos

A woman who is very bored.

How can anyone feel bored in a world with social media, streaming movies, TV shows on-demand and the ability to download just about every book in the world? It may sound paradoxical, but according to a study published in Communications Psychology by Katy Y.Y. Tam and Michael Inzlicht, digital media makes us more bored.

Studies show that since 2010, the amount of time people report feeling bored has increased dramatically and the trend has intensified over the years. Interestingly, people began reporting greater levels of boredom shortly after we all started using social media on our new smartphones.

Why am I bored all the time?

According to researchers, here’s what’s happening. Given that we have access to entertainment whenever we like, the bar for what we consider entertaining or stimulating has increased. It’s like when someone is an addict and they keep needing more and more of the same substance to get the high they crave.

Further, when we engage in less stimulating activities, such as reading a book or attending a class, we feel even more bored than before the digital revolution because we have become accustomed to heightened levels of stimulation.

boredom, psychology, social mediaA woman who is very bored.via Canva/Photos

Another reason flipping through TikTok leaves you feeling bored and listless is that digital media fragments our attention, making it hard to focus on the activity at hand. We quickly switch between videos and activities, our phones pulse and beep with notifications, and texts pop up on the screen, so it’s hard to engage with the content deeply. Also, knowing that we can be distracted at any moment makes it harder to focus. “Digital devices intensify boredom by disrupting attention,” the researchers explain.

“Digital media increases boredom through dividing attention, elevating desired levels of engagement, reducing a sense of meaning, and serving as an ineffective boredom coping strategy,” Tam and Inzlicht argue in their paper.

These findings are supported by a report from the Netherlands’ Radboud University, which recently found that “phone usage wasn't an effective method to alleviate boredom and fatigue and even made these feelings worse in many cases.”

boredom, psychology, social mediaA man who is very bored.via Canva/Photos

As we pointed out with the Dorito Theory a while back, sometimes experiences that aren’t fulfilling can still be maximally addictive. As we scroll and scroll and scroll, trying to come across something that cures our boredom, it’s time to ask ourselves how we feel after the experience. Did logging in deliver the experience we thought we’d get? Or, did the frantic search for content keep us occupied until the boredom crept in again?

Tam says that we can have more meaningful and less boring experiences with digital media if we find longer-form content that we can immerse ourselves in. However, this may prove more complicated than years ago, as our attention spans are much shorter.

“If people want a more enjoyable experience when watching videos, they can try to stay focused on the content and minimize digital switching. Like paying for a more immersive experience in a movie theater, more enjoyment comes from immersing oneself in online videos rather than swiping through them,” Tam writes.





From Your Site Articles
social media
Television

'Freckled Zelda' wows America's Got Talent judges with magical rendition of Disney classic

Even Simon Cowell was stunned by her cover of “Colors of The Wind.”

YouTube

Freckled Zelda singing "Colors of the Wind."

Sometimes, it's easier to be our authentic selves when wearing a costume. That certainly seems to be the case for Freckled Zelda, who went from baffling judges to enchanting them on “America’s Got Talent.”

When then 19-year-old singer arrived on stage in 2022 in full fairy attire (a look inspired by a popular Nintendo character), she initially earned some quizzical looks from the panel. Introducing her instrument, the ocarina, didn’t seem to improve anyone’s first impression leading up to the act. Cowell could only offer the word “interesting,” which, let’s face it, seemed like polite rejection, at best.

But then, she sang. And all bets were off.

Freckled Zelda delivered a soulful rendition of Disney’s “Colors of The Wind” that blew every single listener away. Including Cowell, who admitted, “When you walked out, I thought, ‘wow, this really is going to be terrible,’ and actually you’ve got a really great voice.” She went on to receive a “yes” from all four judges that evening, moving her onto the next round of the competition.

Freckled Zelda’s song choice, with its themes of not judging others who look and think differently, feels entirely appropriate for the moment. Over on TikTok, where it's often cool to be weird, the self-proclaimed “music fairy” already has millions of fans who adore her ethereal persona. And yet, in the real world (and on a mainstream live television show, no less), being different isn't always entirely welcomed.

Freckled Zelda and her unique act received a flood of praise not only from the “AGT” panel, but from the YouTube comments as well. One person wrote, “I love how different she is. She wasn’t swayed when they acted as if she was weird and when she said she can’t change at all; that she would always be a fairy. I love how confident she was! People will support you only if you know what you stand up for.“


At the end of the segment, Heidi Klum noted, “‘America’s Got Talent’ is a variety show and we don’t all have to be the same.” The show has lately had some really diverse triumphs, from a Lebanese belly dance troupe to a Black country singing trio. That list can now include music fairies as well, and we’re here for it.


This article originally appeared two years ago.

From Your Site Articles
video
Trending Stories