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Heroes

199 labs turned him down. This teen made a groundbreaking discovery at the 200th.

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This is Jack Andraka. And trust me, you're going to want to remember that name.

Photo by XPRIZE Foundation/Flickr (altered).


Check out this short video on Jack's unbelievable scientific breakthrough, and then scroll down to see how this teenage whiz kid made it happen.

Jack's beef with pancreatic cancer is a personal one.

At 14, he lost a close family friend to the ruthless and aggressive disease. The pancreas sits deep inside the body and is difficult to scan. There's no hallmark symptom or lump to alert people to the growing danger.

The pancreas (enlarged in red) is nestled right in your abdomen near your liver, stomach, and gallbladder. Image by iStock.

So by the time someone with pancreatic cancer goes to the doctor, it's usually because the disease has spread to other organs. That's why an estimated 72% of patients with pancreatic cancer will die within one year of their diagnosis. And more than 40,000 people die from the disease each year.

But Jack turned his grief into action and set about developing a reliable test for pancreatic cancer.

Passionate about science, Jack ravenously read everything he could about the disease and its biomarkers, characteristics about the disease that are easily measured.

Jack's test for pancreatic cancer is based on a few important but seemingly unrelated ideas. Hold on tight, because it's about to get real science-y in here.

1. Carbon nanotubes are smaller than small — about 1/50,000th the diameter of a human hair. But you can use these microscopic tubes to make tiny networks that conduct electricity.

All GIFs via Upworthy/YouTube.

2. Antibodies like to attach to different proteins in the blood.

3. Mesothelin is one of the biomarkers of pancreatic cancer. It's a protein that the body produces when the cancer is in its early stage.

While Jack was sitting in class one day, it all came together.

As he surreptitiously read an article about carbon nanotubes during class, his biology teacher was giving a lecture on antibodies.

That's when it hit him.

Jack had the brilliant idea to coat a carbon nanotube network with mesothelin. The antibodies would bind to it and get bigger.


As the molecules enlarged, the nanotubes would expand too, changing the network's electrical properties. That change in electricity is quick, easy, and affordable to measure. Eureka!

While Jack had a great working theory, he needed a way to test his hypothesis.

He went home and wrote up his budget, procedure, materials, and timeline, then sent it to 200 cancer research labs, asking for their help. 199 said no.

But one, Dr. Anirban Maitra, then a professor of oncology at Johns Hopkins University and now the chief pancreatic cancer researcher at the University of Texas MD Anderson Cancer Center in Houston, said yes.


With Dr. Maitra's good news, Jack likely did something like this. Photo by iStock.

"It was a very unusual e-mail,” Maitra told Smithsonian Magazine. “I often don’t get e-mails like this from postdoctoral fellows, let alone high-school freshmen.”

Dr. Maitra let him come into the lab at Johns Hopkins to work on his project.

Maitra's yes didn't just come with lab access; it came with the assistance of Maitra's team of Ph.D. researchers, just the kind of team Jack needed to get the job done.

Jack went in after school and on weekends to work on his research. After seven months of preliminary tests and refinements, it started to work.


For his research, Jack has received international recognition and numerous accolades.

Since taking home the 2012 Gordon E. Moore Award, the top prize at the Intel International Science and Engineering Fair, Jack has earned awards and honors from organizations around the globe.


Notably, he received the 2012 Smithsonian American Ingenuity Award, named a Champion of Change by the White House, and received a fellowship as a National Geographic Explorer. And Jack (who came out as gay while still in high school), even earned a spot on Advocate's "40 Under 40" list.

Though Jack's test is promising, it's far from a silver bullet.

His work is extremely preliminary and has yet to be published in a peer-reviewed journal — the industry standard for measuring the merit and veracity of scientific research. Additionally, scientists who have read Andraka's work suggest a need for further research about the speed and price of his test.

Success is within reach but not guaranteed just yet. Photo by iStock.

However, Jack holds a patent on his test and is licensing it to pharmaceutical companies so they can run the often-monotonous clinical trials, a necessary step to ensure patient safety and accurate diagnoses.

"I don't wanna ... end up as a lab rat," Jack said in an interview with "60 Minutes." "I kind of want to be able to come up with a new idea and then really just move on to the next idea, and have other people do the repetitive trials."

In the meantime, Jack, who just turned 19, is keeping busy.

He's a first-year student at Stanford University, gives talks and lectures all over the world, and even co-wrote a memoir, "Breakthrough", about his experience.


And when he's not in the lab, studying for finals, advocating for LGBT youth in STEM careers, or championing pancreatic cancer research, you might find him in his whitewater kayak or catching up with friends and colleagues on social media. You know, typical teenage whiz-kid author/scientist stuff.

He may not fight crime or have special powers, but when it comes to helping others, Jack Andraka has all the makings of a hero.

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Cycle for Survival
Cycle for Survival
Sponsored

How can riding a bike help beat cancer? Just ask Reid Moritz, 10-year-old survivor and leader of his own “wolfpack”

Every year, Reid and his pack participate in Cycle for Survival to help raise money for the rare cancer research that’s helped him and so many others. You can too.

all photos courtesy of Reid Moritz

Together, let’s help fuel the next big breakthrough in cancer research

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There are many things that ten-year-old Reid Wolf Moritz loves. His family, making watches (yes, really), basketball, cars (especially Ferraris), collecting super, ultra-rare Pokémon cards…and putting the pedal to the medal at Cycle for Survival.

Cycle for Survival is the official rare cancer fundraising program of Memorial Sloan Kettering Cancer Center (MSK). One hundred percent of every dollar raised at Cycle for Survival events supports rare cancer research and lifesaving clinical trials at MSK.

At only two years old, Reid was diagnosed with pilocytic astrocytoma, a rare type of brain tumor.

Pediatric cancer research is severely underfunded. When standard treatments don't work, families rely on breakthrough clinical trials to give their children a real shot at long-term survival.

When Reid’s chemotherapy and brain surgery didn’t work, he was able to participate in one of MSK’s clinical trials, where he’s received some incredible results. “Memorial Sloan Kettering has done so much for me. It's just so nice how they did all this for me. They're just the best hospital ever,” Reid recalls.

And that’s why every year, you’ll find Reid with his team, aptly named Reid's Wolfpack, riding at Cycle for Survival. It’s just Reid’s way of paying it forward so that even more kids can have similar opportunities.

“I love sharing my story to inspire other kids to PERSEVERE, STAY STRONG and NEVER GIVE UP while also raising money for my amazing doctors and researchers to help other kids like me.”

Reid remembers the joy felt bouncing on his father’s shoulder and hearing the crowd cheer during his first Cycle for Survival ride. As he can attest, each fundraising event feels more like a party, with plenty of dancing, singing and celebrating.

Hoping to spread more of that positivity, Reid and his family started the Cycle for Survival team, Reid’s Wolfpack, which has raised close to $750,000 over the past eight years. All that money goes directly to Reid’s Neuro-Oncology team at Memorial Sloan Kettering.

In addition to cheering on participants and raising good vibes at Cycle for Survival events, Reid even designs some pretty epic looking merch—like basketball shorts, jerseys, and hoodies—to help raise money.

If you’re looking to help kids just like Reid, and have a ton of fun doing it, you’re in luck. Cycle for Survival events are held at Equinox locations nationwide, and welcome experienced riders and complete newbies alike. You can even join Reid and his Wolfpack in select cities!

And if cycling in any form isn’t your thing, a little donation really does go a long way.

Together, let’s help fuel the next big breakthrough in cancer research. Find out more information by checking out cycleforsurvival.org or filling out this interest form.

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Popular

Millennial dad of 3 shuts down boomer parents for their 'ridiculous' holiday expectations

"Why is it that every time I have to make the effort for you, yet you can't do the most basic thing for me?”

via Canva/Photos

A Millennial dad has had it with his boomer dad's expectations.

A TikTok video posted by @carrerasfam is going viral, with over 300,000 views, because so many millennial parents can relate. In the video, a husband politely but firmly tells his “practically retired” baby boomer dad that he’s not taking his 3 young kids on a 400-mile drive to their house for the holidays.

Carerras Fam is a popular TikTok page about “all things postpartum and mamahood.” The husband opens the conversation with his dad by explaining all the inconveniences of taking 3 young kids on a long road trip. “I know you want us to drive down for the holidays, but it's kinda ridiculous that you want me to pack my 3 kids with their portable beds with my clothes, their clothes, the formula, everything that goes on with raising 3 kids and having them feel comfortable. Drive down for over four hours just so that we could spend some time in your house?” the husband says.

@carrerasfam

Sorry it’s just so much work. But you’re welcome to visit us #millennial #millennials #parents #parenting #parentsontiktok #boomers #millennials

It’s obviously inconvenient for the couple to pack up their kids and drive 4 hours, but it’s also unsafe because the house is not baby-proof. "I'm gonna have to run around, make sure that they don't break any of your stuff, and which you will take care of them,” the husband continues using sarcastic air quotes.

The dad brings up another great point: His parents are in good health, so why don’t they drive to their house? “You could visit. You don't have little kids,” the dad continues. “You don't have anything going on.

"Why is it that every time I have to make the effort for you, yet you can't do the most basic thing for me?”

It’s clear from the phone call the dad understands that traveling with the kids and staying in a house that isn’t correctly set up for young kids will make the holiday a struggle. Instead of making memories, they’ll most likely be running around bent over trying to save their kids from breaking something or hanging out at Target buying electrical socket plugs and a bottle brush because they left theirs at home.



The video struck a chord with many millennial parents.

“First holiday with a kid… parents are confused why I won’t drive 9 hours with a 3mnth old for Christmas,” too_many_catz writes. “The ‘not baby proofed’ part hit my soullllllll. It’s so stressful having to chase your kids around and ask to close doors, move pictures, block stairs, etc. And nobody takes you seriously!" OhHeyItsIndy added.

It’s also expensive for young families to travel. “Add to it they want us to spend money on gas, airfare, etc. when we live paycheck to paycheck and rent while they own homes and live comfortably off a pension,” another user wrote.

This one hit hard: “They always act like you're asking the world of them, yet they will willingly go on any other vacation that they choose,” Mackenzie Byrne wrote.

TX Travel Chick may have hit the nail on the head with her explanation for why boomer parents expect their children to road trip it to their house for the holidays. “Because we are used to following their orders!!! REVOLT,” she wrote.

Ultimately, it would be interesting to learn why boomer parents want to inconvenience their kids when it would be much easier for them to take a trip to see them, especially if they can afford a hotel. One wonders if they are being entitled or if they’ve forgotten how hard it is to travel with young kids.

Race & Ethnicity

10 Black women sat in first class on an airplane and it revealed a lot about race in America

"This weekend I went on a girls trip. 10 Black women flying first class. People literally could not process how it was possible."

via Angie Jones / Twitter and Matt Blaze / Flickr

Software developer Angie Jones' recent girls trip revealed that America still has a long way to go when it comes to race. To most, that's not surprising. But what's unique is how the specific experience Jones and her friends went through revealed the pervasive way systemic racism still runs through our culture.

Jones is the Senior Director of Developer Relations at Applitools, holds 26 patented inventions in the United States of America and Japan, and is an IBM Master Inventor.

On July 27, she tweeted about a flight she took with nine other Black women and they all sat in first class. "People literally could not process how it was possible," she wrote. "Staff tried to send us to regular lines. Passengers made snide remarks. One guy even yelled 'are they a higher class of people than I am?!'"

Jones and her friends were the targets of racism that ranged from the seemingly unconscious — people who assumed that Black people don't sit in first class — to the blatant — those who were seriously bothered that Black people were being treated as having a higher status.

It's interesting that she didn't mention anyone saying "good for you" for succeeding in a world that often holds people of color back. Instead, she was greeted with incredulity and jealous rage.

There are a lot of white people who can't stand the idea of a Black person being elevated above them. It's disturbing that in there are still some who will admit it publicly.

Jones' tweets inspired a lot of people to share their stories about the racism they've experienced while flying first class.

Jones' tweets also angered some people to the point that they denied her story. To which she responded, "To those saying I'm lying, you're a huge part of the problem," she wrote. "You tell yourself a notable person is lying (for what reason, I cannot figure out) before you believe there are actual racists in...America."

One Twitter user came up with the perfect retort to the person who asked, "Are they a higher class of people than I am?!"

This article originally appeared three years ago.

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Innovation

A student accidentally created a rechargeable battery that could last 400 years

"This thing has been cycling 10,000 cycles and it’s still going." ⚡️⚡️

Steve Zylius/University of California, Irvine.

There's an old saying that luck happens when preparation meets opportunity.

There's no better example of that than a 2016 discovery at the University of California, Irvine, by doctoral student Mya Le Thai. After playing around in the lab, she made a discovery that could lead to a rechargeable battery that could last up to 400 years. That means longer-lasting laptops and smartphones and fewer lithium ion batteries piling up in landfills.

A team of researchers at UCI had been experimenting with nanowires for potential use in batteries, but found that over time the thin, fragile wires would break down and crack after too many charging cycles. A charge cycle is when a battery goes from completely full to completely empty and back to full again.

But one day, on a whim, Thai coated a set of gold nanowires in manganese dioxide and a Plexiglas-like electrolyte gel.

"She started to cycle these gel capacitors, and that's when we got the surprise," said Reginald Penner, chair of the university's chemistry department. "She said, 'this thing has been cycling 10,000 cycles and it's still going.' She came back a few days later and said 'it's been cycling for 30,000 cycles.' That kept going on for a month."

This discovery is mind-blowing because the average laptop battery lasts 300 to 500 charge cycles. The nanobattery developed at UCI made it though 200,000 cycles in three months. That would extend the life of the average laptop battery by about 400 years. The rest of the device would have probably gone kaput decades before the battery, but the implications for a battery that that lasts hundreds of years are pretty startling.

Batteries being recycled at WRWA, London. Nov ‘21Photo by John Cameron on Unsplash

"The big picture is that there may be a very simple way to stabilize nanowires of the type that we studied," Penner said. "If this turns out to be generally true, it would be a great advance for the community." Not bad for just fooling around in the laboratory.


This article originally appeared two years ago.

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Innovation

Astronaut shares the profound 'big lie' he realized after seeing the Earth from space

This change in perspective could change humanity.

via Rubén Moreno Montolíu/Flickr

Our home, from space.

Sixty-one years ago, Yuri Gagarin became the first human to make it into space and probably the first to experience what scientists now call the "overview effect." This change occurs when people see the world from far above and notice that it’s a place where “borders are invisible, where racial, religious and economic strife are nowhere to be seen.”

The overview effect makes man’s squabbles with one another seem incredibly petty and presents the planet as it truly is, one interconnected organism.

In a compelling interview with Big Think, astronaut, author and humanitarian Ron Garan explains how if more of us developed this planetary perspective we could fix much of what ails humanity and the planet.

Garan has spent 178 days in space and traveled more than 71 million miles in 2,842 orbits. From high above, he realized that the planet is a lot more fragile than he thought.

“When I looked out the window of the International Space Station, I saw the paparazzi-like flashes of lightning storms, I saw dancing curtains of auroras that seemed so close it was as if we could reach out and touch them. And I saw the unbelievable thinness of our planet's atmosphere. In that moment, I was hit with the sobering realization that that paper-thin layer keeps every living thing on our planet alive,” Garan said in the video.

“I saw an iridescent biosphere teeming with life,” he continues. “I didn't see the economy. But since our human-made systems treat everything, including the very life-support systems of our planet, as the wholly owned subsidiary of the global economy, it's obvious from the vantage point of space that we're living a lie.”

It was at that moment he realized that humanity needs to reevaluate its priorities.

“We need to move from thinking economy, society, planet to planet, society, economy. That's when we're going to continue our evolutionary process,” he added.

Garan says that we are paying a very “high price” as a civilization for our inability to develop a more planetary perspective and that it’s a big reason why we’re failing to solve many of our problems. Even though our economic activity may improve quality of life on one end, it’s also disasterous for the planet that sustains our lives.

It’s like cutting off our nose to spite our face.

Actor William Shatner had a similar experience to Garan's when he traveled into space.

"It was among the strongest feelings of grief I have ever encountered," Shatner wrote. "The contrast between the vicious coldness of space and the warm nurturing of Earth below filled me with overwhelming sadness. Every day, we are confronted with the knowledge of further destruction of Earth at our hands: the extinction of animal species, of flora and fauna … things that took five billion years to evolve, and suddenly we will never see them again because of the interference of mankind."

“We're not going to have peace on Earth until we recognize the basic fact of the interrelated structure of all reality,” Garan said.

However dire the situation looks from the surface of Earth, the astronaut has hope that we can collectively evolve in consciousness and wake up and embrace a larger reality. “And when we can evolve beyond a two-dimensional us versus them mindset, and embrace the true multi-dimensional reality of the universe that we live in, that's when we're going to no longer be floating in darkness … and it's a future that we would all want to be a part of. That's our true calling.”


This article originally appeared two years ago.

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Wellness

Doctor explains how to do a simple physical test that can predict your longevity

People who fail are more likely to die in six years.

via Pexels

A woman sitting cross-legged on a yoga mat

Everyone wants to know how long they will live and there are many indicators that can show whether someone is thriving or on the decline. But people have yet to develop a magic formula to determine exactly how long someone should expect to live.

However, a doctor recently featured on the "Today" show says a straightforward test can reveal the likelihood that someone aged 51 to 80 will die in the near future. NBC News medical contributor Dr. Natalie Azar was on the "Today" show on March 8 and demonstrated how to perform the simple “sit to stand test” (aka sit-rising test or SRT) that can help determine the longevity of someone between 51 to 80.

The test is pretty simple. Go from standing to sitting cross-legged, and then go back to standing without using any parts of your body besides your legs and core to help you get up and down. The test measures multiple longevity factors, including heart health, balance, agility, core and leg strength and flexibility.

You begin the test with a score of 10 and subtract points on your way up and down for doing the following:

Hand used for support: -1 point

Knee used for support: -1 point

Forearm used for support: -1 point

One hand on knee or thigh: -1 point

Side of leg used for support: -1 point

A 2012 study published by the European Society of Cardiology found a correlation between the SRT score and how long people live. The study was conducted on 2002 people, 68% of whom were men, who performed the SRT test and were followed by researchers in the coming years. The study found that “Musculoskeletal fitness, as assessed by SRT, was a significant predictor of mortality in 51–80-year-old subjects.”

Those who scored in the lowest range, 0 to 3, had up to a 6 times greater chance of dying than those in the highest scores (8 to 10). About 40% of those in the 0 to 3 range died within 11 years of the study.

Azar distilled the study on "Today," saying: "The study found that the lower the score, you were seven times more likely to die in the next six years.”

"Eight points or higher is what you want," Azar said. "As we get older, we spend time talking cardiovascular health and aerobic fitness, but balance, flexibility and agility are also really important," she stressed.

One should note that the people who scored lowest on the test were the oldest, giving them an elevated risk of death.

Dr. Greg Hartley, Board Certified Geriatric Clinical Specialist and associate professor at the University of Miami, told the Atlanta Journal-Constitution that we should take the study with a grain of salt. “Frailty, strength, muscle mass, physical performance—those things are all correlated to mortality, but I would caution everybody that correlation doesn’t mean causation,” he said.

And of course, the test doesn't take into account injuries or disabilities that may make doing the test impossible. But one of the study's authors says that the study is a call to take our mobility seriously.

“The more active we are the better we can accommodate stressors, the more likely we are to handle something bad that happens down the road,” Dr. Claudio Gil Araujo, told USA Today.


This article originally appeared a year ago.

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