upworthy
Heroes

199 labs turned him down. This teen made a groundbreaking discovery at the 200th.

True
The CW

This is Jack Andraka. And trust me, you're going to want to remember that name.

Photo by XPRIZE Foundation/Flickr (altered).



Check out this short video on Jack's unbelievable scientific breakthrough, and then scroll down to see how this teenage whiz kid made it happen.

Jack's beef with pancreatic cancer is a personal one.

At 14, he lost a close family friend to the ruthless and aggressive disease. The pancreas sits deep inside the body and is difficult to scan. There's no hallmark symptom or lump to alert people to the growing danger.

The pancreas (enlarged in red) is nestled right in your abdomen near your liver, stomach, and gallbladder. Image by iStock.

So by the time someone with pancreatic cancer goes to the doctor, it's usually because the disease has spread to other organs. That's why an estimated 72% of patients with pancreatic cancer will die within one year of their diagnosis. And more than 40,000 people die from the disease each year.

But Jack turned his grief into action and set about developing a reliable test for pancreatic cancer.

Passionate about science, Jack ravenously read everything he could about the disease and its biomarkers, characteristics about the disease that are easily measured.

Jack's test for pancreatic cancer is based on a few important but seemingly unrelated ideas. Hold on tight, because it's about to get real science-y in here.

1. Carbon nanotubes are smaller than small — about 1/50,000th the diameter of a human hair. But you can use these microscopic tubes to make tiny networks that conduct electricity.

All GIFs via Upworthy/YouTube.

2. Antibodies like to attach to different proteins in the blood.

3. Mesothelin is one of the biomarkers of pancreatic cancer. It's a protein that the body produces when the cancer is in its early stage.

While Jack was sitting in class one day, it all came together.

As he surreptitiously read an article about carbon nanotubes during class, his biology teacher was giving a lecture on antibodies.

That's when it hit him.

Jack had the brilliant idea to coat a carbon nanotube network with mesothelin. The antibodies would bind to it and get bigger.


As the molecules enlarged, the nanotubes would expand too, changing the network's electrical properties. That change in electricity is quick, easy, and affordable to measure. Eureka!

While Jack had a great working theory, he needed a way to test his hypothesis.

He went home and wrote up his budget, procedure, materials, and timeline, then sent it to 200 cancer research labs, asking for their help. 199 said no.

But one, Dr. Anirban Maitra, then a professor of oncology at Johns Hopkins University and now the chief pancreatic cancer researcher at the University of Texas MD Anderson Cancer Center in Houston, said yes.


With Dr. Maitra's good news, Jack likely did something like this. Photo by iStock.

"It was a very unusual e-mail,” Maitra told Smithsonian Magazine. “I often don’t get e-mails like this from postdoctoral fellows, let alone high-school freshmen.”

Dr. Maitra let him come into the lab at Johns Hopkins to work on his project.

Maitra's yes didn't just come with lab access; it came with the assistance of Maitra's team of Ph.D. researchers, just the kind of team Jack needed to get the job done.

Jack went in after school and on weekends to work on his research. After seven months of preliminary tests and refinements, it started to work.


For his research, Jack has received international recognition and numerous accolades.

Since taking home the 2012 Gordon E. Moore Award, the top prize at the Intel International Science and Engineering Fair, Jack has earned awards and honors from organizations around the globe.


Notably, he received the 2012 Smithsonian American Ingenuity Award, named a Champion of Change by the White House, and received a fellowship as a National Geographic Explorer. And Jack (who came out as gay while still in high school), even earned a spot on Advocate's "40 Under 40" list.

Though Jack's test is promising, it's far from a silver bullet.

His work is extremely preliminary and has yet to be published in a peer-reviewed journal — the industry standard for measuring the merit and veracity of scientific research. Additionally, scientists who have read Andraka's work suggest a need for further research about the speed and price of his test.

Success is within reach but not guaranteed just yet. Photo by iStock.

However, Jack holds a patent on his test and is licensing it to pharmaceutical companies so they can run the often-monotonous clinical trials, a necessary step to ensure patient safety and accurate diagnoses.

"I don't wanna ... end up as a lab rat," Jack said in an interview with "60 Minutes." "I kind of want to be able to come up with a new idea and then really just move on to the next idea, and have other people do the repetitive trials."

In the meantime, Jack, who just turned 19, is keeping busy.

He's a first-year student at Stanford University, gives talks and lectures all over the world, and even co-wrote a memoir, "Breakthrough", about his experience.


And when he's not in the lab, studying for finals, advocating for LGBT youth in STEM careers, or championing pancreatic cancer research, you might find him in his whitewater kayak or catching up with friends and colleagues on social media. You know, typical teenage whiz-kid author/scientist stuff.

He may not fight crime or have special powers, but when it comes to helping others, Jack Andraka has all the makings of a hero.

A map of the United States post land-ice melt.

Land ice: We got a lot of it. Considering the two largest ice sheets on earth — the one on Antarctica and the one on Greenland — extend more than 6 million square miles combined ... yeah, we're talkin' a lot of ice. But what if it was all just ... gone? Not like gone gone, but melted?

If all of earth's land ice melted, it would be nothing short of disastrous. And that's putting it lightly. This video by Business Insider Science (seen below) depicts exactly what our coastlines would look like if all the land ice melted. And spoiler alert: It isn't great. Lots of European cities like, Brussels and Venice, would be basically underwater.

I bring up the topic not just for funsies, of course, but because the maps are real possibilities.

How? Climate change.

As we continue to burn fossil fuels for energy and emit carbon into our atmosphere, the planet gets warmer and warmer. And that, ladies and gentlemen, means melted ice.

A study published this past September by researchers in the U.S., U.K., and Germany found that if we don't change our ways, there's definitely enough fossil fuel resources available for us to completely melt the Antarctic ice sheet.

Basically, the self-inflicted disaster you see above is certainly within the realm of possibility.


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In Africa and the Middle East? Dakar, Accra, Jeddah — gone.



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Millions of people in Asia, in cities like Mumbai, Beijing, and Tokyo, would be uprooted and have to move inland.



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South America would say goodbye to cities like Rio de Janeiro and Buenos Aires.


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And in the U.S., we'd watch places like Houston, San Francisco, and New York City — not to mention the entire state of Florida — slowly disappear into the sea.


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All GIFs via Business Insider Science/YouTube.

Business Insider based these visuals off National Geographic's estimation that sea levels will rise 216 feet (!) if all of earth's land ice melted into our oceans.

There's even a tool where you can take a detailed look at how your community could be affected by rising seas, for better or worse.

Although ... looking at these maps, it's hard to imagine "for better" is a likely outcome for many of us.

Much of America's most populated regions would be severely affected by rising sea levels, as you'll notice exploring the map, created by Alex Tingle using data provided by NASA.

Take, for instance, the West Coast. (Goodbye, San Fran!)



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Or the East Coast. (See ya, Philly!)


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And the Gulf Coast. (RIP, Bourbon Street!)

"This would not happen overnight, but the mind-boggling point is that our actions today are changing the face of planet Earth as we know it and will continue to do so for tens of thousands of years to come," said lead author of the study Ricarda Winkelmann, of the Potsdam Institute for Climate Impact Research.

If we want to stop this from happening," she says, "we need to keep coal, gas, and oil in the ground."

The good news? Most of our coastlines are still intact! And they can stay that way, too — if we act now.

World leaders are finallystarting to treat climate change like the global crisis that it is — and you can help get the point across to them, too.

Check out Business Insider's video below:


- YouTubewww.youtube.com


This article originally appeared eleven years ago.

Sustainability

Walking Alongside Martu: A journey with one of the world’s oldest living cultures

Pura’s inaugural impact collection honors both sacred traditions and sustainable futures.

James Roh
True

In a world driven by speed, efficiency, and immediate results, it’s easy to forget that lasting change is built on trust. Real impact doesn’t come from rushing toward an end goal or measuring success through lofty metrics. It comes from falling in love with the problem, building a community around it, and sharing a vision for lasting transformation.

Pura, the smart home fragrance company that marries premium fragrance with innovative technology, recently launched its inaugural impact collection with K Farmer Dutjahn Foundation (KFDF) and Dutjahn Sandalwood Oils (DSO). The Pura x Dutjahn partnership began with a clear purpose: to source a sacred ingredient directly from its origin while honoring the land and the people who’ve cared for it. Our goal wasn’t simply to find sandalwood — it was to find a community and an ingredient that embody exceptional land stewardship, ethical harvesting, and transformative, community-led impact. After careful research and over three years of development, we saw an opportunity to secure a premium, luxurious ingredient while supporting a regenerative supply chain that invests in Indigenous-led education, economic opportunity, and land stewardship.

James Roh

Over the past several years, we’ve walked alongside Martu, an Indigenous tribe from the vast Western Australian desert. Martu are one of the oldest living cultures in the world, with a history spanning 60,000 years. As nomadic hunter-gatherers, they have unparalleled ecological knowledge, passed down through generations, making them the traditional custodians of the land. Their approach to sandalwood harvesting isn’t driven by market demand but by a deep respect for seasonal rhythms, land health, and cultural law. Their work adapts to the environment—whether it’s “sorry time,” when mourning pauses activities, or the harsh desert conditions that make travel and communication difficult. Martu operate on Martu time, a deliberate rhythm shaped by millennia of experience, far removed from the rapid-swipe, hyper-productive pace of Western systems.

Martu’s ecological knowledge isn’t documented in baseline reports. It’s lived, carried in stories, and practiced with rigor and respect for the changing needs of the ecosystems. True partnership means unlearning the typical approach. It means standing beside—not in front—and recognizing that the wisdom and leadership we need already exist within these communities. Our role isn’t to define the work, but to support it, protect it, and learn from it.

James Roh

Tonight, as I spoke with Chairman Clinton Farmer and the KFDF team about our focus for this piece, I learned that Clinton’s truck had broken down (again), leaving him to “limp” back to town from the desert at low speeds for hours and hours. He had been awake since 3:00 a.m. This is a common and costly setback, one that disrupts the harvest, demands days of driving, and brings real financial and emotional strain. These barriers are relentless and persistent, part of the harsh reality Clinton and his community face daily. It's easy for outsiders, detached from the reality on the ground, to impose rules, regulations, and demands from afar. Rather than continuing to impose, we need to truly partner with communities — equipping them with the resources to operate sustainably, avoid burnout, and protect the very land they love and care for. All while they endeavor to share these incredible, sacred ingredients with the world and build an economic engine for their people.

There is much to learn, but we are here to listen, adapt, and stay the course. The future we need will not be built in quarterly cycles. It will be built in trust, over time, together.

To learn more about the partnership and fragrances, visit Pura x Dutjahn.

Health

Science confirms ‘Move in Silence’ trend might be the smartest way to achieve your goals

“I promise you things always work out better when you keep them to yourself.”

Science confirms ‘Move in Silence’ trend might be the smartest way to achieve your goals.

TikTok's latest viral wisdom is backed by hard data—and it's making people rethink their communication habits. We live in a world of chronic oversharing. We post everything, from the routes we run (including screenshots as proof of all that hard work), to the pale-green iced matcha latte sitting at our desks or a present from a boyfriend (who will be tagged prominently, not secretly off screen). Who knows when, but our brains became wired for sharing: to record, to curate, and to post every second of our lives, then consume that of others to a disturbing degree. So, here's a radical idea: when it comes to goals and plans, try keeping them to yourself. It could be the key to making them a reality.

That's the message behind TikTok's massively popular "Move in Silence" trend, where creators like @noemoneyyy have cracked the contradictory code to success: Instead of broadcasting every big idea or project that runs through your head, if you actually want it to come to fruition, keep your plans to yourself until they're executed. And it's not just a trend; surprisingly, science also supports this muted approach.


"As a former oversharer who used to tell every single friend, every single family member, or a partner everything I was doing, I promise you things always work out better when you keep them to yourself," explains creator @noemoneyyy in a video that's garnered millions of views.

On a different video by @mandanazarfhami, she says, “I don’t care what you’ve got going on in your life: that dream job, that city that you want to move to, that dream person, that dream life, that dream anything. Literally keep it to yourself until it’s done.”

Commentors were quick to agree, with one person writing: “From a young age, I never told anyone my next steps. I also taught my husband and son to keep our private matters to themselves and just do things 💯Not many people like it, but who cares🌝🙌🏼🫶🏼”

Another chimed in, “This concept has changed my life for the better.” Others replied, “100 agree 💕” and “100%🙌🏼people can’t ruin what is silent, show results.”


@mandanazarghami monitoring spirits are a real thing - move in silence and watch how much your life changes #fypシ ♬ Jacob and the Stone - Emile Mosseri


What's going on here

In a study done by New York University, researchers found that people who kept their goals private worked on tasks for an average of 45 minutes, compared to the 33 minutes of work completed by those who announced their plans in advance. The twist? The people who shared their goals expressed feeling closer to finishing, despite doing approximately 25% less work.

NYU psychologist Peter Gollwitzer, who led the research, concluded that "once you've told other people your intentions, it gives you a 'premature sense of completeness.'" He also found that the brain is made up of "identity symbols," which create one's self-image. Interestingly, both action and talking about action create symbols in your brain, so simply speaking about a future plan or something you want to do satisfies that part of your brain. When we make our goals public, especially ones that matter to us and deal with our identity, our ability to achieve said goal is significantly reduced. As the old adage goes, "actions speak louder than words."

Stranger still, in his paper "Does Social Reality Widen the Intention-Behavior Gap," Gollwitzer notes that in order for this phenomenon to happen, one must truly care about their goals. "Ironically, this effect was only found for participants who are very committed to their goal!" PsychologyToday notes. "The lesson learned is that the more passionate you are about your goals, the more secretive you should be about them."

Quiet, silence, peace, shhh, no speaking, secret The more passionate you are about your goals, the more secretive you should be. Photo credit: Canva

Another reason to keep quiet: If you're a beginner trying something new, sharing your plans could potentially open you up to criticism and negative feedback, which could deter you from even starting. At the University of Chicago, professor Ayelet Fishbach conducted studies to determine how positive and negative feedback affects the pursuit of one's goal. According to Atlassian, she and her team found:

  • When positive feedback signals commitment to a goal, it increases motivation.
  • When positive feedback signals progress, it actually decreases motivation.
"One example the researchers give is a math student who gets a good grade on a test. If she perceives it to mean she likes math, she will study harder. If, however, she sees the high score as a sign she is making progress in the class, she may ease up and study less." - Atlassian


@_alliechen I used to be such an open book but now im a lot more reserved on my goals and plans so ppl dont judge #moveinsilence #relateablecontent #girlies #viral #success ♬ suara asli - astrooo🪐

We've all been there: excitedly telling everyone about your grand plans to backpack through Europe, the year you'll finally learn Spanish, or joining the group lesson at the tennis courts you always pass by… only to mysteriously lose all motivation a week later. Turns out, those lovely dopamine bursts that accompany every enthusiastic "That sounds great!" or "You should totally do it!" response might be precisely what's holding you back.

The good news? You don't need to become closed-off and secretive, a hermit on the top of a mountain who's afraid to share any part of themselves with the world. Research suggests that sharing your goals with one or two selected friends who can be trusted to provide meaningful support is still a good idea. Just hold off on the Instagram Live announcement until you've actually accomplished something substantial.

So, the next time you sit down to write your goals, whether they be a new year's resolution, the day's to-do list, or a five-year plan, think twice about sharing it with others. Give it time and you might have something better to share soon: the results.

A woman thinking to herself.

Ever have a moment in your life when someone told you something wise that you’ve never heard before, and it felt like time stopped? You feel so grateful to have the wisdom, but at the same time, sad because you wish you had heard it earlier and avoided some of life's unnecessary trials and tribulations.

One of the primary reasons we remember some things people tell us and forget others is emotion. When we experience an emotional reaction to information, the brain perceives it as valuable and stores it in long-term memory. That’s probably why it’s easy to remember the lyrics to the songs we love. The words are combined with an emotional change created by the melody in which they are sung and the accompanying music.

A Reddit user asked people on the AskReddit subforum to share the phrases they “heard only once but it stayed with you forever,” and it inspired a wonderful conversation where people shared the timeless wisdom that they will never forget. Many of the phrases revolved around healthy ways to deal with relationships, making sense of inner dialogues, and how to change, even when it feels impossible.

truth, wisdom, wise phrases, man thinking, mind blown, great advice, memoryA man after hearing great advice. via Canva/Photos

Here are 15 of the most inspiring quotes that people “heard only once,” but they have stayed with them forever.

1. "You can't un-ring a bell."

"My high school history teacher told us - speak carefully to others, you can't un-drive the nail, the hole will always remain. Someone may forgive you, but the damage is done, the hole will remain."

"The axe forgets, but the tree remembers."

2. “You don’t have to attend every argument you’re invited to.”

"I cannot tell you how many times over the last few years I have had to stop and physically tell myself, that it's not my job to make sure anyone understands anything. Helped me put down my phone a number of times and just breath."

"The best thing to learn early in life is to walk away. Some ppl actually think they won the argument because I walked away. I feel like I won because I walked away."



3. "Sometimes, a man on the right track gets hit by a train on the wrong one."

"It is possible to commit no mistakes and still lose. That is not a weakness; that is life." - Jean Luc Picard

4. "Don’t confuse being needed with being valued."

"Ouch to that. To add to the confusion: true friendships can arise from responding to a need, and there are people who are really nice to you when they need you. But once you hit a bump on the road and become useless, even if just for a while, reactions vary."


truth, wisdom, wise phrases, man thinking, mind blown, great advice, memoryA woman thinking about some sage advice.via Canva/Photos

5. "Not everyone you lose is a loss."

"This is good advice, especially for people going through a life change (e.g., growing up, moving, graduating, switching jobs, etc). A lot of people have drifted out of my life over the years, and a lot more made me sad at the time than were actually worth getting sad about. A few departures might've even been worthy of celebration, but it didn't feel that way in the moment."

"As I grow older, I've realized a very important skill for my own mental health is being able to cherish and appreciate the person someone was, and even love them, while also appreciating some extra distance between our present selves."

6. "Don't believe everything you think."

"I needed this. Having some hang-xiety from this weekend on how I’m a total weirdo & I need to learn to stfu more. But I know the reality is I just opened up and made new friends."

"Having worked with and known people with mental health struggles, I will say, 'A (depressed or mentally unwell) brain is a liar. It will tell you things that aren’t true. Keep a list of what is real and the facts that support it."

7. "No matter how far down the wrong road you are... turn around."

"The longer it takes you to get off the bus, the more expensive the return ticket will be."

"When you realize you are in a hole, stop digging."


truth, wisdom, wise phrases, man thinking, mind blown, great advice, memoryA man after hearing great advice.via Canva/Photos

8. "The way you talk to / scold your kids is the voice and tone they will learn to talk to themselves in."

"Similarly, I've read, 'Your anger becomes their anxiety.' As a new mom who was raised by an angry father and struggles with anxiety, it is a perspective I'm glad I came upon early. It has redirected both how I speak to her and what I'll allow her to be exposed to."

"God, I feel that. My parents were basically always angry and/or annoyed."

9. "You are under no obligation to set yourself on fire to keep someone else warm."

"That one always makes me think of something my therapist said: 'You didn’t ask to be born. Your parents wanted a child and you have lived to fulfil their wants and needs for twenty years. You’re allowed to live for yourself now.'"

10. “If you don’t ask, the answer will always be no.”

"You miss 100% of the shots you don't take in a different form."


11. "Grief is just love with nowhere to go."

"There have been a few similar phrases about grief that have stuck with me:

'The culmination of love is grief, and yet we love despite the inevitable, we open our hearts to it. To grieve deeply is to have loved fully.

And "But what is grief but love persevering.'

Both tore me to pieces and have stuck with me as I've lost people close to me."


12. "The time will pass either way."

"I heard this phrase once in the context of someone who was talking about wanting to go to med school and become a doctor, but they were already in their 30s. They were saying something like, 'I really want to do it but its 7 years! If I start now, I won't become a doctor til I'm 42.' And the other person responded: 'And how old will you be in 7 years if you don't go to med school? The time will pass regardless.'"

13. "Just because you lost me as a friend, doesn’t mean you gained me as an enemy. I still want to see you eat, just not at my table."

"My old boss used to say, 'I wish you well and I wish you away.'"

14. "In the absence of communication, the void is filled with negativity."

"Lack of effective communication in a close personal relationship, a business/professional relationship, a political relationship, etc. can lead to negative assumptions about how they might feel about you, create perceptions of incompetence, or increase suspicions/distrust."

15. "Don't let 'perfect' be the enemy of progress."

"The version we were talking about at my work just today was 'Perfection is the enemy of getting shit done.'"













Pop Culture

People agree these 19 things are weirdly romanticized, but are actually huge red flags

"The idea of someone cheating on their spouse to pursue you. How is that romantic? Please be serious."

One person's romantic is another person's cringe.

We all love a good love story. The grand gestures, the unbridled spontaneity, and those "against all odds” moments that give relationships a dose of movie magic are everything. But, sometimes, the things we’ve been taught to swoon over—whether that be due to pop culture or more overarching societal trends—are actually pretty toxic when you stop to think about them.

Recently, someone asked folks to share their own examples of behaviors that are “weirdly romanticized” but are actually major red flags once you look past the glossy surface, and honestly, it’s eye-opening.

Here are some of the most surprising (and perhaps unsettling) examples they shared. One major category belonged to those tropes we see in many, many television shows, movies, and even songs…

1. "Having someone who is completely obsessed with you."

dating, modern dating, dating apps, romance, romance tips, relationships, relationship red flags, relationship green flagsmedia1.giphy.com

2. "Enemies to lovers. It's cute in theory, but how can you be with someone when you know all the disgusting things they've said about you before your relationship?"

3. "I used to love the 'asshole-to-everyone-except-you' trope until he started being an asshole to my friends. Some tropes are meant to stay fictional."

4. "The 'I'm just a girl' trend and other TikTok trends that are used to deflect any accountability or responsibility as an adult human being."

dating, modern dating, dating apps, romance, romance tips, relationships, relationship red flags, relationship green flagsmedia4.giphy.com

5. "The idea of someone cheating on their spouse to pursue you. How is that romantic? Please be serious."

6. "Pressuring someone to hurry up and put a ring on it."

Two people brought differing, yet equally important views on work/love life balance.

7. "Sacrificing your professional or personal life to pursue someone."

8. "Honestly, I think we conflate hard work with unhealthy boundaries between the self and career, and we romanticize working overtime, long shifts, and doing excessive tasks as a display of personal growth. We've manipulated ourselves into feeling that giving our time to pursue our work is noble. I'm saying this as a student in medicine, where hours are absolutely wild. I know I'll work my hardest, but I won't sacrifice my sense of self and my time to eke out my own passions and life just to get ahead in my career track. At least, I hope I don't lose sight of myself in the pursuit of following my dreams. It can be really hard not to notice that that's where you're headed until you've already sacrificed so much."

How folks handle—or don’t handle—conflict also was a major red flag.

9. "Not being confrontational. Needless confrontation is bad, but sometimes, you do need to confront someone."

10. "Fighting all the time. No, it doesn't mean that your relationship is 'passionate.' It means that you're probably incompatible and shouldn't be together."

dating, modern dating, dating apps, romance, romance tips, relationships, relationship red flags, relationship green flagsmedia.giphy.com

Finally, this category belongs to things that many people think often carry a hidden warning, even if they seem workable, even harmless, at first.

11. "I knew a girl whose boyfriend went everywhere with her. He wouldn't let her go anywhere if he weren't there, and she thought it was cute how 'possessive' he was over her. It thoroughly icked me out when she told me. Like, that is not healthy at all."

12. "Being a 'free spirit.' Like, there's a gray area, but there's a time and place to be inhibited and misbehave. Not following rules in public settings because you're 'free' gets old really fast."

13. "Being the charismatic 'heavy drinker' in friend groups. Goes for men and women."

14. "When people say things like, 'He's just broken,' as if it's something romantic. Having pain doesn't justify cruelty, and loving someone shouldn't mean bleeding just to make them feel whole."

15. "People who brag about not being interested in reading or learning. Here in the US, there is a huge anti-curiosity or anti-intellect movement, and people will literally brag about being ignorant."

16. "Being over controlling. My coworker thinks it's adorable when they say stuff like, 'My husband would kill me if I got a tattoo there!' Gross. Sorry that your husband is so fragile."

17. "People who constantly post about their partner. It's not romantic, it's performative. Real love doesn't need a PR campaign."

18. "'Traditional values.'"

dating, modern dating, dating apps, romance, romance tips, relationships, relationship red flags, relationship green flagsmedia3.giphy.com

Lastly, perhaps the oldest red flag in the book…

19. "The idea that playing games or being 'hard to get' in a cruel way will make their crush or interest want them more."

Note the one gesture that no one mentioned as un-romantic: flowers. Just sayin'.